PMID: 2115005Jan 1, 1990Paper

The crosslinking theory of aging--added evidence

Experimental Gerontology
J Bjorksten, H Tenhu

Abstract

The crosslinking theory of aging has been gaining acceptance at a steady pace, as evidenced by many independent rediscoveries. While several earlier studies were indicative, none seemed conclusive until it was shown, using Differential Scanning Calorimetry (DSC), that protein from young human brains could be made to closely resemble protein from old brains by exposing it to either of two entirely different crosslinking agents (glutaraldehyde and dipotassium diperoxy sulfate). This work has now been repeated with additional brain material, and a statistically more significant number of determinations. It is now shown that a treatment of brain protein with either one or two chemically totally different compounds which have no property in common except that both are crosslinkers, changes young brain protein so that it greatly resembles old, crosslinked protein. This shows that crosslinking reactions are involved in the age related changes in the studied proteins.

References

May 11, 1973·Science·M L Tanzer
Sep 1, 1980·Mechanisms of Ageing and Development·I Nagy, K Nagy
Jul 1, 1956·Journal of Gerontology·D HARMAN
Apr 1, 1965·Journal of Gerontology·D G CARPENTER
Jan 1, 1960·Journal of Gerontology·R R KOHN, E ROLLERSON

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Citations

Jan 1, 1995·Molecular Aspects of Medicine·S I Rattan
Jan 1, 1996·Experimental Gerontology·S I Rattan
Sep 3, 2011·Rejuvenation Research·Sven Bulterijs
Nov 21, 2017·Ecology and Evolution·Brian S DorrCarol A Furcolow
Aug 12, 2014·PloS One·Gavin C WoodruffEric S Haag
Mar 1, 2018·Biochemistry. Biokhimii︠a︡·R F Walker
Mar 8, 2017·The Journal of Biological Chemistry·Alexey GolubevVadim N Gladyshev
Feb 11, 2021·The Journal of Investigative Dermatology·Meinhard WlaschekKarin Scharffetter-Kochanek
Jun 17, 2020·Ageing Research Reviews·Alexander Fedintsev, Alexey Moskalev
Jan 15, 2004·Journal of the American Chemical Society·Gary L JuskowiakDavid L Van Vranken

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