The crustacean ecdysone cassette: A gatekeeper for molt and metamorphosis

The Journal of Steroid Biochemistry and Molecular Biology
Cameron J HydeTomer Ventura

Abstract

Arthropods have long been utilized as models to explore molecular function, and the findings derived from them can be applied throughout metazoa, including as a basis for medical research. This has led to the adoption of many representative insect models beyond Drosophila, as each lends its own unique perspective to questions in endocrinology and genetics. However, non-insect arthropods are yet to be realised for the potential insight they may provide in such studies. The Crustacea are among the most ancient arthropods from which insects descended, comprising a huge variety of life histories and ecological roles. Of the events in a typical crustacean development, metamorphosis is perhaps the most ubiquitous, challenging and highly studied. Despite this, our knowledge of the endocrinology which underpins metamorphosis is rudimentary at best; although several key molecules have been identified and studied in depth, the link between them is quite nebulous and leans heavily on well-explored insect models, which diverged from the Pancrustacea over 450 million years ago. As omics technologies become increasingly accessible, they bring the prospect of explorative molecular research which will allow us to uncover components and pathway...Continue Reading

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Citations

Jun 4, 2020·Environmental Science and Pollution Research International·Jeremy Jaegers, Eric Gismondi
May 29, 2021·Aquatic Toxicology·Rikke PoulsenNina Cedergreen
Jun 29, 2021·Frontiers in Cell and Developmental Biology·Jan TaubenheimSebastian Fraune
Aug 22, 2021·The Journal of Steroid Biochemistry and Molecular Biology·Huwei YuanYan Wu

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