The Cryoablation for Peripheral Pulmonary Lesions Using a Novel Flexible Bronchoscopic Cryoprobe in the ex vivo Pig Lung and Liver

Respiration; International Review of Thoracic Diseases
Xiaoxuan ZhengJiayuan Sun

Abstract

Percutaneous cryoablation has been used for the treatment of lung cancer and has been shown to be safe and effective. However, some lung cancer lesions cannot be reached by percutaneous puncture; using bronchoscopy cryoablation is necessary in these cases. To examine the efficiency and security of a flexible cryoprobe, we measured the size and temperature distribution of the frozen area (ice ball) in ex vivo pig lung and liver and the temperature of the bronchoscope. We evaluated flexible cryoprobe cryoablation using a bronchoscope in ex vivo pig lung and a flexible cryoprobe alone in ex vivo pig liver. Seven temperature sensors were positioned at the surface of the cryoprobe and at distances of 0.3, 0.6, 0.9, 1.2, 1.5, and 1.8 cm from the cryoprobe. Two temperature sensors were positioned at the surface of the bronchoscope. The ex vivo pig lung and liver were perfused with 37°C saline and the former was inflated using a ventilator to simulate in vivo lung conditions. The whole operation is usually 2-3 freezing cycles. In ex vivo pig liver, probes made ice balls of 33.2 ± 0.2 mm in diameter. In ex vivo pig lung, probes made ice balls of 35.1 ± 1.7 mm in diameter. The temperature at the surface of the bronchoscope at distances o...Continue Reading

References

Oct 1, 1985·Cryobiology·G JacobB J Fuller
Jul 22, 1998·Urology·S C CampbellA C Novick
Apr 3, 2004·Technology in Cancer Research & Treatment·J K Seifert, T Junginger
Dec 29, 2004·The Annals of Thoracic Surgery·Yotaro IzumiKoichi Kobayashi
May 9, 2006·The Journal of Thoracic and Cardiovascular Surgery·Masafumi KawamuraKoichi Kobayashi
Oct 17, 2009·Cryobiology·A A GageJ G Baust
Jul 9, 2010·Journal of the American College of Surgeons·Alla ZemlyakThomas V Bilfinger
May 26, 2012·Journal of Vascular and Interventional Radiology : JVIR·Hyun J BangAllen C Goodman
May 26, 2012·European Journal of Radiology·Xiao ZhangYue-Yong Xiao
Jul 31, 2012·Journal of Vascular and Interventional Radiology : JVIR·Nobutake ItoSachio Kuribayashi
Mar 5, 2013·Journal of Vascular and Interventional Radiology : JVIR·Hideki YashiroSachio Kuribayashi
Jan 24, 2015·Journal of Vascular and Interventional Radiology : JVIR·Yusuke MatsuiSusumu Kanazawa
Mar 5, 2015·Journal of Vascular and Interventional Radiology : JVIR·William MooreThomas Bilfinger
Jan 9, 2016·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Nov 12, 2016·Medical Oncology·Roberto Luigi CazzatoAfshin Gangi

❮ Previous
Next ❯

Citations

Feb 6, 2020·American Journal of Respiratory and Critical Care Medicine·Gerard J CrinerFelix J Herth
Jul 10, 2020·Respirology : Official Journal of the Asian Pacific Society of Respirology·Daniel P Steinfort, Felix J F Herth

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.