The cryoglobulinemic syndrome--report from the workshop on classification and on the 10th conference of the Italian Society for the treatment of Cryoglobulinemia, Modena, 29 Sept., 2003

Zeitschrift für Rheumatologie
Peter Lamprecht

Abstract

The conference was preceded by a workshop of an European expert group on the n evaluation, testing, and workup of a new classification for cryoglobulinemic syndrome. Several studies on the potential role of infections, especially hepatitis C virus (HCV) and cytomegalovirus (CMV), in the pathogenesis of human autoimmune diseases were presented and discussed at the conference. A cross-reactivity between CMV proteins and different auto-antigens could play a role with respect to the initial endothelial damage in the pathogenesis of systemic sclerosis. A number of immune mechanisms may be involved in the induction of the cryoglobulinemic syndrome such as the formation of cross-reacting antibodies, chronic B-cell stimulation, an interaction between the HCV core protein and tumor suppressor genes p53 and/or proto-oncogens, and the t(14;18) translocation with bcl-2 activation and prolonged B-cell survival.

Citations

May 17, 2011·Annals of the Rheumatic Diseases·S De VitaM Galli

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