PMID: 9546221Apr 18, 1998Paper

The crystal structure of Dps, a ferritin homolog that binds and protects DNA

Nature Structural Biology
R A GrantJ M Hogle

Abstract

The crystal structure of Dps, a DNA-binding protein from starved E. coli that protects DNA from oxidative damage, has been solved at 1.6 A resolution. The Dps monomer has essentially the same fold as ferritin, which forms a 24-mer with 432 symmetry, a hollow core and pores at the three-fold axes. Dps forms a dodecamer with 23 (tetrahedral) point group symmetry which also has a hollow core and pores at the three-folds. The structure suggests a novel DNA-binding motif and a mechanism for DNA protection based on the sequestration of Fe ions.

References

Jan 19, 1978·Nature·S H BanyardP M Harrison
Nov 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·H S YuanR E Dickerson
Nov 2, 1990·Cell·M B Schmid
Jul 1, 1994·Nature Structural Biology·F FrolowJ Yariv
Jan 5, 1993·Journal of Molecular Biology·G D Van DuyneJ Clardy
Sep 5, 1993·Journal of Molecular Biology·L Holm, C Sander
Dec 1, 1995·The Biochemical Journal·N E Le BrunA J Thomson
Feb 1, 1996·Journal of Bacteriology·R J BrentjensS M Spinola
Jul 31, 1996·Biochimica Et Biophysica Acta·P M Harrison, P Arosio
Aug 1, 1997·Journal of Bacteriology·A Martinez, R Kolter
Sep 1, 1994·Acta Crystallographica. Section D, Biological Crystallography·UNKNOWN Collaborative Computational Project, Number 4
Jul 1, 1996·Acta Crystallographica. Section D, Biological Crystallography·D H JacobsonD J Filman
Jan 1, 1997·Methods in Enzymology·Zbyszek Otwinowski, Wladek Minor

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Citations

Nov 26, 2002·Journal of Molecular Recognition : JMR·Jennifer LittlechildMisha Isupov
Nov 24, 1999·Biochemical and Biophysical Research Communications·A OlsenS I Rattan
Dec 31, 2004·Journal of Biosciences·Aashiq Hussain Kachroo
Jun 2, 2007·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Jana TaturPedro M Matias
Jun 29, 2010·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Kourosh Honarmand EbrahimiWilfred R Hagen
Oct 9, 2002·Journal of Molecular Biology·Giuseppe ZanottiCesare Montecucco
Apr 15, 2003·Journal of Molecular Biology·Hyung Jun AhnSe Won Suh
May 28, 2003·Journal of Molecular Biology·Bin RenRudolf Ladenstein
Jul 31, 2002·Biochimica Et Biophysica Acta·Sabine ReindelBerthold F Matzanke
Apr 3, 2001·Current Opinion in Microbiology·S M McLeod, R C Johnson
May 14, 1999·Current Opinion in Microbiology·G Storz, J A Imlay
May 14, 1999·Current Opinion in Microbiology·T Nyström
Oct 1, 2009·Chemical Reviews·Zhen MaDavid P Giedroc
Oct 10, 2013·Inorganic Chemistry·Elizabeth C Theil
Oct 30, 2013·Journal of the American Chemical Society·Thomas A CornellBrendan P Orner
Sep 8, 2011·Chemical Communications : Chem Comm·Xenia VinzenzLars-Oliver Essen
Feb 5, 1999·The Biochemical Journal·S StefaniniE Chiancone
Apr 25, 2001·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·K Yamanaka, M Inouye
Oct 3, 2008·Proceedings of the National Academy of Sciences of the United States of America·Timothy BowlesBrandt F Eichman
Mar 16, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jason M Sobota, James A Imlay
Jul 20, 2011·The Journal of Biological Chemistry·Jelena PesekKornelius Zeth
Nov 22, 2008·Antioxidants & Redox Signaling·F Wayne Outten, Elizabeth C Theil
Oct 28, 2010·Antioxidants & Redox Signaling·Melinda J Faulkner, John D Helmann
Feb 4, 2011·Nucleic Acids Research·Sundari ChodavarapuJon M Kaguni
Mar 3, 2006·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Pedro M MatiasWilfred R Hagen
Jan 6, 2011·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Takanori MiyamotoYoshinori Satow
Dec 23, 2004·Molecular Microbiology·Audrey BrenotMichael G Caparon
Oct 13, 2006·Infection and Immunity·Ge WangRobert J Maier
Feb 24, 2004·Infection and Immunity·J SeshuJonathan T Skare
Feb 26, 2013·Journal of Bacteriology·Luciano F HuergoVictoria Korolik
Nov 14, 2006·Journal of Bacteriology·Jenny A HydeJonathan T Skare

❮ Previous
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