The crystal structure of human cyclin H

FEBS Letters
G AndersenJ C Thierry

Abstract

The crystal structure of human cyclin H has been solved at 2.6 A resolution by the MIR method and refined to an R-factor of 23.1%. The core of the molecule consists of two helical repeats adopting the canonical cyclin fold already observed in the structures of cyclin A [Brown et al. (1995) Structure 3, 1235-1247; Jeffrey et al. (1995) Nature 376, 313-320; Russo et al. (1996) Nature 382, 325-331] and TFIIB [Nikoilov et al. (1995) Nature 377, 119-128]. The N-terminal and C-terminal residues form a new domain built on two long helices interacting essentially with the first repeat of the molecule.

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Citations

Jul 19, 2013·Biochemical Society Transactions·Jane A Endicott, Martin E M Noble
Jun 23, 1998·Structure·J A Endicott, M E Noble
Feb 19, 2015·Nature Reviews. Molecular Cell Biology·Sarah SainsburyPatrick Cramer
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