PMID: 8610159Apr 2, 1996Paper

The crystal structure of human glycosylation-inhibiting factor is a trimeric barrel with three 6-stranded beta-sheets

Proceedings of the National Academy of Sciences of the United States of America
Y KatoR Kuroki

Abstract

Glycosylation-inhibiting factor (GIF) is a cytokine that is involved in the regulation of IgE synthesis. The crystal structure of recombinant human GIF was determined by the multiple isomorphous replacement method. The structure was refined to an R factor of 0.168 at 1.9 angstrom resolution. The overall structure is seen to consist of three interconnected subunits forming a barrel with three 6-stranded beta-sheets on the inside and six alpha-helices on the outside. There is a 5-angstrom-diameter "hole" through the middle of the barrel. The barrel structure of GIF in part resembles other "trefoil" cytokines such as interleukin 1 and fibroblast growth factor. Each subunit has a new class of alpha + beta sandwich structure consisting of two beta-alpha-beta motifs. These beta-alpha-beta motifs are related by a pseudo-twofold axis and resemble both interleukin 8 and the peptide binding domain of major histocompatibility complex protein, although the topology of the polypeptide chain is quite different.

References

Jun 17, 1976·Nature·M Levitt, C Chothia
Sep 1, 1976·The Journal of Experimental Medicine·D B MurphyH O McDevitt
Apr 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·A E ErikssonB W Matthews
Apr 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·J D ZhangS R Sprang
Oct 20, 1989·Journal of Molecular Biology·B C FinzelH M Einspahr
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J P PriestleM G Grütter
Mar 16, 1989·Nature·E Y JonesN P Walker
May 15, 1973·Journal of Molecular Biology·S T Rao, M G Rossmann
Jan 1, 1984·Annual Review of Immunology·K Ishizaka
Sep 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·M KronenbergL Hood
Sep 26, 1995·Proceedings of the National Academy of Sciences of the United States of America·T NakanoK Ishizaka
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·Y C LiuK Ishizaka
Oct 15, 1993·Structure·C A Orengo, J M Thornton
Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·T MikayamaK Ishizaka

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Citations

Jun 1, 1996·Current Opinion in Structural Biology·A G Murzin
Aug 1, 1997·Current Opinion in Structural Biology·E Gouaux
Apr 5, 2002·Microbes and Infection·Hongqi LueJürgen Bernhagen
Jun 19, 2013·Proceedings of the National Academy of Sciences of the United States of America·Chengpeng FanElias J Lolis
Jun 18, 1998·Annals of the New York Academy of Sciences·R Bucala
May 13, 1997·Proceedings of the National Academy of Sciences of the United States of America·K SugieK Ishizaka
Jan 7, 1997·Proceedings of the National Academy of Sciences of the United States of America·T NakanoK Ishizaka
Nov 9, 2000·Proceedings of the National Academy of Sciences of the United States of America·H WataraiY Ishii
Sep 1, 2000·International Immunology·K KasaharaK Imai
Nov 2, 2016·Expert Opinion on Therapeutic Targets·Joshua BloomYousef Al-Abed
Mar 20, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·K Sugie, J Huang
Aug 8, 1997·Biochemical and Biophysical Research Communications·A Galat, F Bouet
Aug 28, 2018·Journal of Chemical Information and Modeling·Mustafa Tekpinar, Ahmet Yildirim

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