PMID: 7536631Apr 7, 1995Paper

The CTL's kiss of death

Cell
G Berke

Abstract

The potent and specific lytic activity of CTLs can occur by at least two distinct pathways. In the secretion and perforin-mediated pathway, the direct effect(s) on the target cell membrane of the pore-forming agent perforin, probably in conjunction with granzymes, also secreted from the CTLs, causes the target's demise. Intercytoplasmic transfer of granzymes is believed to be involved in inducing target apoptosis. In the Fas-mediated pathway, engagement of a CTL membrane ligand with an apoptosis-inducing target cell surface receptor, such as the FasL with Fas, triggers programmed disintegration of the CTL-bound target; secretion of granzymes and pore formation by perforin are not involved in this receptor-mediated mechanism. Despite the fundamental differences in their onset for both pathways, the downstream sequence of events that culminate in target cell apoptosis appears to be similar. Further studies will resolve this enigma.

References

Jan 1, 1991·Annual Review of Immunology·E R PodackM G Lichtenheld
Apr 1, 1994·European Journal of Immunology·F RamsdellD H Lynch
May 10, 1994·Proceedings of the National Academy of Sciences of the United States of America·S T JuA Marshak-Rothstein
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·C M WalshW R Clark
Feb 2, 1995·Nature·A Strasser
Jan 1, 1993·The Journal of Experimental Medicine·E RouvierP Golstein
Apr 1, 1994·Current Opinion in Immunology·P H KrammerK M Debatin
Sep 10, 1993·Cell·L A TartagliaD V Goeddel

❮ Previous
Next ❯

Citations

Jan 14, 1998·International Journal of Cancer. Journal International Du Cancer·S DiasF Balkwill
Jul 15, 1999·International Journal of Cancer. Journal International Du Cancer·K ChikamatsuT L Whiteside
Jul 9, 1999·Reviews in Medical Virology·P Griffiths
Feb 5, 1998·Annals of Neurology·I M Fyhr, A Oldfors
Dec 24, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D VermijlenE Wisse
Feb 11, 1998·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·T Patel, G J Gores
Feb 16, 2000·Biochemical and Biophysical Research Communications·Y OkudaT Yanagihara
Jan 1, 1996·Springer Seminars in Immunopathology·R L BolhuisJ W Gratama
Feb 28, 1998·Immunologic Research·K KajinoM I Greene
Jul 1, 1995·Immunology Today·G Berke
Mar 1, 1996·Trends in Microbiology·J Tschopp, K Hofmann
Jun 29, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Joel G R WeaverAndrew D Badley
Apr 28, 2004·Microbes and Infection·Kathleen L Collins
Mar 20, 1999·Transplantation Proceedings·V SubbotinA S Rao
Jul 7, 1999·Neuroscience and Biobehavioral Reviews·K VedharaE C Wang
Aug 15, 2002·Journal of Hepatology·Jung-Hwan Yoon, Gregory J Gores
Apr 15, 1997·Human Immunology·G Berke
Feb 20, 1999·Cancer Letters·E C ShinS J Kim
Mar 1, 1997·Clinics in Dermatology·J MalejczykS Jabłońska
Mar 1, 1997·Research in Immunology·C M Eischen, P J Leibson
Apr 18, 1998·Biochimica Et Biophysica Acta·R PíoN López-Moratalla
Jan 9, 1998·Baillière's Clinical Haematology·P G Ekert, D L Vaux
Apr 1, 1996·Current Opinion in Immunology·B A Osborne
Apr 12, 2003·Microbes and Infection·Donald R Drake, Thomas J Braciale
Sep 19, 2008·Nature Immunology·Morgan HuseMark M Davis
Dec 22, 1999·The Biochemical Journal·M RechsteinerV Ustrell
Dec 3, 1999·European Journal of Clinical Investigation·F L DumoulinU Spengler
Apr 16, 1998·Immunology·T Yamazaki, Y Aoki
Apr 29, 1998·Immunology and Cell Biology·L F Lincz
Oct 29, 2008·Seminars in Liver Disease·Harmeet Malhi, Gregory J Gores

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cell eTOC

Cell is a scientific journal publishing research across a broad range of disciplines within the life sciences field. Discover the latest research from Cell here.