The Cucurbit[7]Uril-Based Supramolecular Chemistry for Reversible B/Z-DNA Transition

Advanced Science
Shao-Ru WangXiang Zhou

Abstract

As a left-handed helical structure, Z-DNA is biologically active and it may be correlated with transcription and genome stability. Until recently, it remained a significant challenge to control the B/Z-DNA transition under physiological conditions. The current study represents the first to reversibly control B/Z-DNA transition using cucurbit[7]uril-based supramolecular approach. It is demonstrated that cucurbit[7]uril can encapsulate the central butanediamine moiety [HN(CH2)4NH] and reverses Z-DNA caused by spermine back to B-DNA. The subsequent treatment with 1-adamantanamine disassembles the cucurbit[7]uril/spermine complex and readily induces reconversion of B- into Z-DNA. The DNA conformational change is unequivocally demonstrated using different independent methods. Direct evidence for supramolecular interactions involved in DNA conformational changes is further provided. These findings can therefore open a new route to control DNA helical structure in a reversible way.

References

Jan 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·Y LiW D Wilson
May 17, 1996·The Journal of Biological Chemistry·A Herbert, A Rich
Oct 12, 2000·Proceedings of the National Academy of Sciences of the United States of America·X QuJ B Chaires
Nov 28, 2001·The Journal of Organic Chemistry·A DayB Snushall
Mar 27, 2003·Acta Crystallographica. Section D, Biological Crystallography·Anirban Ghosh, Manju Bansal
Jul 3, 2003·Nature Reviews. Genetics·Alexander Rich, Shuguang Zhang
Oct 30, 2003·Journal of the American Chemical Society·Yan XuHiroshi Sugiyama
Jul 30, 2005·Angewandte Chemie·Jason LagonaLyle Isaacs
Nov 10, 2005·Journal of the American Chemical Society·Simin LiuLyle Isaacs
Feb 14, 2006·Proceedings of the National Academy of Sciences of the United States of America·Guliang WangKaren M Vasquez
Feb 5, 2009·Nucleic Acids Research·Jaroslav KyprMichaela Vorlícková
Mar 31, 2009·Journal of the American Chemical Society·Debapriya MazumdarYi Lu
Jan 12, 2010·Journal of the American Chemical Society·Sharmistha Dutta ChoudhuryAchikanath C Bhasikuttan
May 5, 2010·Proceedings of the National Academy of Sciences of the United States of America·Matteo de RosaMaria Armenia Carrondo
May 13, 2010·Chemical Society Reviews·Dana A UhlenheuerLuc Brunsveld
Jul 30, 2010·The Journal of Physical Chemistry. B·Juyong LeeChaok Seok
Sep 10, 2010·Chemistry : a European Journal·Issei DoiShigeki Sasaki
Dec 22, 2010·Journal of the American Chemical Society·Sangsu BaeSungchul Hohng
Dec 22, 2010·Proceedings of the National Academy of Sciences of the United States of America·Bimal K RayAlpana Ray
Jan 25, 2011·Biophysical Chemistry·Vorasit VongsutilersPeter M Gannett
Feb 1, 2011·Journal of the American Chemical Society·Jameson R BotheHashim M Al-Hashimi
Apr 5, 2011·Nucleic Acids Research·Krzysztof BrzezinskiZbigniew Dauter
May 4, 2011·Journal of the American Chemical Society·D Calvin HarrisJanarthanan Jayawickramarajah
Jul 19, 2011·Journal of the American Chemical Society·Jeane M GovanAlexander Deiters
Sep 9, 2011·Chemical Society Reviews·Jungkweon Choi, Tetsuro Majima
Nov 15, 2011·Journal of the American Chemical Society·Hao TangCornelia Bohne
Dec 20, 2011·Chemical Communications : Chem Comm·Alfredo Medina-Molner, Bernhard Spingler
Feb 9, 2013·Chemical Reviews·Osman DolucaVyacheslav V Filichev
Apr 11, 2013·Nucleic Acids Research·Atsushi MaruyamaKen Itoh
Aug 27, 2013·Nucleic Acids Research·Matteo de RosaAlekos Athanasiadis
Sep 17, 2013·Angewandte Chemie·Liping CaoLyle Isaacs
Oct 17, 2013·Dalton Transactions : an International Journal of Inorganic Chemistry·Jung Kyu ChoiMilan Balaz
Jan 3, 2014·Angewandte Chemie·Liping CaoLyle Isaacs
May 21, 2014·Angewandte Chemie·Hong Hee LeeHugh I Kim
Oct 31, 2014·Journal of the American Chemical Society·Zhichang LiuJ Fraser Stoddart
May 7, 2015·Scientific Reports·Yoon Jung JangSeog K Kim

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Citations

Sep 27, 2018·Chemical Communications : Chem Comm·X ZhouJ Jayawickramarajah
Aug 29, 2020·Angewandte Chemie·Yao-Hua LiuYu Liu
Nov 19, 2020·Chemical Communications : Chem Comm·Ekaterina Y Chernikova, Daria V Berdnikova
Jun 15, 2021·Chemical Science·Xue WangGuangyan Qing
Aug 12, 2021·Organic & Biomolecular Chemistry·Mohammad A AlnajjarAndreas Hennig
Nov 21, 2020·Journal of the American Chemical Society·Catherine A J HooperMichael J Hannon
Oct 23, 2018·Analytical Chemistry·Yufeng ZhouYong Shao

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Methods Mentioned

BETA
circular dichroism
fluorescence titrations
NMR
Fluorescence

Software Mentioned

MestReNova

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