The cumulative effect of small vessel disease lesions is reflected in structural brain networks of memory clinic patients

NeuroImage. Clinical
Rutger HeinenUtrecht Vascular Cognitive Impairment Study Group

Abstract

Mechanisms underlying cognitive impairment in patients with small vessel disease (SVD) are still unknown. We hypothesized that cognition is affected by the cumulative effect of multiple SVD-related lesions on brain connectivity. We therefore assessed the relationship between the total SVD burden on MRI, global brain network efficiency, and cognition in memory clinic patients with vascular brain injury. 173 patients from the memory clinic of the University Medical Center Utrecht underwent a 3 T brain MRI scan (including diffusion MRI sequences) and neuropsychological testing. MRI markers for SVD were rated and compiled in a previously developed total SVD score. Structural brain networks were reconstructed using fiber tractography followed by graph theoretical analysis. The relationship between total SVD burden score, global network efficiency and cognition was assessed using multiple linear regression analyses. Each point increase on the SVD burden score was associated with 0.260 [-0.404 - -0.117] SD units decrease of global brain network efficiency (p < .001). Global network efficiency was associated with information processing speed (standardized B = -0.210, p = .004) and attention and executive functioning (B = 0.164, p = .04...Continue Reading

Citations

Nov 21, 2019·Journal of Neurology, Neurosurgery, and Psychiatry·Anil M TuladharFrank-Erik De Leeuw
Feb 28, 2020·Brain Connectivity·Bruno M de Brito RobaloUNKNOWN Utrecht VCI Study Group
Jul 25, 2019·Stroke and Vascular Neurology·Jing Du, Qun Xu
Oct 4, 2019·PloS One·Catherine A SpillingThomas R Barrick
Aug 19, 2020·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Sofia FinsterwalderMarco Duering
Oct 29, 2019·Journal of Alzheimer's Disease : JAD·Emma RichardsAndrea Tales
Oct 9, 2019·Journal of Alzheimer's Disease : JAD·Emma RichardsAndrea Tales
Aug 14, 2019·Journal of Alzheimer's Disease : JAD·Wenhao ZhuWei Wang
Jun 25, 2019·Frontiers in Neurology·Doeschka FerroYael Reijmer
Mar 6, 2021·AJNR. American Journal of Neuroradiology·N RaposoA Viswanathan

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