The Current and Future Therapies for Human Osteosarcoma

Current Cancer Therapy Reviews
Joseph D LamplotHue H Luu

Abstract

Osteosarcoma (OS) is the most common non-hematologic malignant tumor of bone in adults and children. As sarcomas are more common in adolescents and young adults than most other forms of cancer, there are a significant number of years of life lost secondary to these malignancies. OS is associated with a poor prognosis secondary to a high grade at presentation, resistance to chemotherapy and a propensity to metastasize to the lungs. Current OS management involves both chemotherapy and surgery. The incorporation of cytotoxic chemotherapy into therapeutic regimens escalated cure rates from <20% to current levels of 65-75%. Furthermore, limb-salvage surgery is now offered to the majority of OS patients. Despite advances in chemotherapy and surgical techniques over the past three decades, there has been stagnation in patient survival outcome improvement, especially in patients with metastatic OS. Thus, there is a critical need to identify novel and directed therapy for OS. Several Phase I trials for sarcoma therapies currently ongoing or recently completed have shown objective responses in OS. Novel drug delivery mechanisms are currently under phase II and III clinical trials. Furthermore, there is an abundance of preclinical researc...Continue Reading

Citations

Oct 25, 2016·Journal of the Mechanical Behavior of Biomedical Materials·S ChauhanA Prasad
Oct 21, 2016·Rheumatology and Therapy·Ryan A DurfeeHue H Luu
Jan 4, 2020·Journal of Cellular Biochemistry·Jun ZhangZhiwei Liu
Sep 18, 2020·Technology in Cancer Research & Treatment·Ju Yeon OhEun Ho Kim
Oct 18, 2020·International Journal of Molecular Sciences·Anita K Luu, Alicia M Viloria-Petit
May 29, 2021·International Journal of Nanomedicine·Sasmita SamalMamoni Dash
Jun 12, 2021·Cancer Chemotherapy and Pharmacology·Kazuhisa SugiuToshiyoshi Fujiwara
Aug 13, 2021·Investigational New Drugs·Khaliunsarnai TsogtbaatarLigia Rodrigues
Aug 28, 2021·Genes·Emel RothzergSulev Kõks

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