The current endeavors to understand the pathogenesis of intractable liver diseases

The Tohoku Journal of Experimental Medicine
Yoshiyuki Ueno

Abstract

The death due to liver diseases accounts for more the 35,000 cases every year in Japan for decades. Among these liver diseases, the Ministry of Health, Labor, and Welfare of Japan has named both fulminant hepatitis and primary biliary cirrhosis (PBC) as intractable liver diseases, since the precise mechanism of these diseases are unclear. Accordingly, there are no effective medical treatments other than liver transplantation toward these diseases. However, still the number of the liver transplantation performed in Japan is small. Thus, we have focused on the pathogenesis of these two intractable conditions. The fulminant hepatitis is a distinct form of acute hepatitis, and hepatitis B virus infection accounts for 20~30% of this lethal condition. Only tiny proportions of patients with acute HBV infection develop fulminant hepatitis (less than 10%). It has been widely believed both viral and host factors contribute for fulminant hepatitis, although still unknown factors are expected to be involved. On the other hand, PBC is a chronic progressive cholestatic liver disease. Clinical features of PBC include female predominance (80 to 90%), the presence of antimitochondrial antibody (up to 95%), and elevated serum levels of immunoglo...Continue Reading

References

Dec 20, 1994·Proceedings of the National Academy of Sciences of the United States of America·S K RobertsN F LaRusso
Jan 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·Y UenoN F LaRusso
Feb 1, 1997·The American Journal of Physiology·G AlpiniN F LaRusso
Mar 25, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y UenoS Nagata
Jun 16, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·G LesageG Alpini
Oct 27, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G AlpiniG Lesage
Jul 2, 2003·Proceedings of the National Academy of Sciences of the United States of America·Lizhe XuAndrew Mason
Feb 28, 2004·Liver International : Official Journal of the International Association for the Study of the Liver·Yoshiyuki UenoTooru Shimosegawa
Jan 28, 2005·The Tohoku Journal of Experimental Medicine·Jun InoueTooru Shimosegawa
Jan 13, 2006·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Keiichi TamaiTooru Shimosegawa
Oct 24, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kanji WakabayashiM Eric Gershwin
Jan 30, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yuki MoritokiM Eric Gershwin
May 6, 2008·Clinics in Liver Disease·Ya-Hui ChuangM Eric Gershwin
Dec 17, 2008·World Journal of Gastroenterology : WJG·Takayuki KogureTooru Shimosegawa
Feb 12, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Pietro Lampertico, Massimo Colombo
Apr 17, 2009·Journal of Gastroenterology and Hepatology·Yoshiyuki UenoGeoffrey C Farrell
Apr 23, 2009·Journal of Gastroenterology and Hepatology·Deepak AmarapurkarUNKNOWN Asia-Pacific Working Party on Prevention of Hepatocellular Carcinoma
Oct 14, 2009·Laboratory Investigation; a Journal of Technical Methods and Pathology·Osamu KidoTooru Shimosegawa
Oct 31, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yuki MoritokiM Eric Gershwin
Nov 4, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Eiji KakazuTooru Shimosegawa
Feb 17, 2010·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Hiromitsu KumadaUNKNOWN Study Group for the Standardization of Treatment of Viral Hepatitis Including Cirrhosis, Ministry of Health, Labor and Welfa
Feb 17, 2010·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Hiromitsu KumadaUNKNOWN Study Group for the Standardization of Treatment of Viral Hepatitis Including Cirrhosis, Ministry of Health, Labour and Welf
Feb 17, 2010·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Koji FukushimaTooru Shimosegawa
Mar 13, 2010·Current Opinion in Gastroenterology·Yoshiyuki UenoM Eric Gershwin
May 14, 2010·Journal of Hepatology·Noriyuki ObaraTooru Shimosegawa
Jan 19, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·George V Papatheodoridis
Oct 19, 2011·International Journal of Hepatology·Masashi NinomiyaTooru Shimosegawa

❮ Previous
Next ❯

Citations

Jan 11, 2013·BioFactors·Laura Vera-RamirezJosé L Quiles
Sep 28, 2014·Technology in Cancer Research & Treatment·Li Li LinDong Min Qiu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Hepatology
Masashi NinomiyaTooru Shimosegawa
Liver International : Official Journal of the International Association for the Study of the Liver
Yuki MoritokiTooru Shimosegawa
Hepatology Research : the Official Journal of the Japan Society of Hepatology
Yuki MoritokiTooru Shimosegawa
Hepatology Research : the Official Journal of the Japan Society of Hepatology
Koji FukushimaTooru Shimosegawa
© 2022 Meta ULC. All rights reserved