The current evidence for a biomarker-based approach in cancer of unknown primary

Cancer Treatment Reviews
Elie El Rassy, Nicholas Pavlidis

Abstract

Cancer of unknown primary (CUP) accounts for the seventh to eighth most frequently diagnosed cancer yet its prognosis remains poor with conventional chemotherapy. The spectrum of therapeutic management includes both locoregional and systemic therapy and should intend to offer optimal benefit to favorable CUP patients and palliative care to unfavorable cases. The recent molecular advances have revolutionized the armamentarium of cancer treatments though a biomarker-based approach. Unfortunately, solid data in CUP is lacking in the absence of a CUP-specific driver molecular signature. This prompted us to screen the medical literature for clinical data that evaluates the efficacy and safety of the biomarker-based approach in CUP patients. In this review, we will summarize the available evidence for the applicability of targeted therapies in CUP.

Citations

Mar 26, 2019·European Journal of Clinical Investigation·Elie El RassyNicholas Pavlidis
Aug 7, 2019·Future Oncology·Elie RassyNicholas Pavlidis
May 31, 2019·International Journal of Cancer. Journal International Du Cancer·Nicholas PavlidisJulie Smith-Gagen
Jan 24, 2020·International Journal of Cancer. Journal International Du Cancer·Tilmann BochtlerAlwin Krämer
Apr 21, 2020·The Oncologist·Brianna R BakowThomas A Ollila
Aug 12, 2020·Expert Review of Anticancer Therapy·Elie Rassy, Nicholas Pavlidis
Feb 12, 2020·British Journal of Cancer·Elie RassyNicholas Pavlidis
May 1, 2020·Nature Reviews. Clinical Oncology·Elie Rassy, Nicholas Pavlidis
Jun 17, 2019·International Journal of Clinical Oncology·Elie RassyNicholas Pavlidis
Dec 12, 2020·Future Oncology·Nicholas PavlidisUNKNOWN ESO-AROME Survey Participants
Feb 28, 2020·Critical Reviews in Oncology/hematology·Elie RassyNicholas Pavlidis
Jun 25, 2020·Journal of Advanced Research·Aline KhazzakaNicholas Pavlidis
Feb 3, 2020·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Elie RassyNicholas Pavlidis
May 11, 2021·European Journal of Clinical Investigation·Elie RassyNicholas Pavlidis
Jul 25, 2021·Scientific Reports·Hamidreza Aboulkheyr EsMehdi Totonchi

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