The current functional state of local neuronal circuits controls the magnitude of a BOLD response to incoming stimuli

NeuroImage
Frank AngensteinHenning Scheich

Abstract

The purpose of this study was to determine how the history-dependent activation state of neuronal networks controls fMRI signals to incoming stimuli. Simultaneous electrophysiological and blood oxygen level-dependent (BOLD) responses were monitored during stimulation of the perforant pathway with low, high, and again low intensity but, otherwise identical pulse trains. Under three different anesthetics (alpha-chloralose, medetomidine, isoflurane) consecutive low intensity stimulation trains, set just below the threshold for population spike generation to single pulses, yielded a stable BOLD response, although at different magnitudes. The first high intensity train increased the BOLD response under all anesthetics and generated population spikes, with varying amplitudes and latencies (alpha-chloralose, metedomidine) or in a regular pattern (isoflurane). Concurrent to the second high intensity train, the BOLD response became minimal, then slowly increasing with subsequent trains (alpha-chloralose, metedomidine), or immediately rising to a stable level (isoflurane). Second train population spikes became regularized, but at low amplitudes and long latencies that were slowly reversed across trains (alpha-chloralose, medetomidine); w...Continue Reading

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Citations

Jun 5, 2010·Nonlinear Biomedical Physics·Arvid Lundervold
Dec 2, 2015·NeuroImage·Christina Y ShuFahmeed Hyder
Jan 8, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Thomas Scherf, Frank Angenstein
Aug 25, 2011·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Karla Krautwald, Frank Angenstein
Dec 15, 2011·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Regina TiedeFrank Angenstein
Mar 1, 2019·Scientific Reports·Yoshifumi AbeLuisa Ciobanu
Jun 29, 2011·Future Microbiology·Claudia Sala, Ruben C Hartkoorn
Oct 18, 2019·Frontiers in Neuroscience·Jeyeon LeeSu-Youne Chang

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