The current landscape of psoriasis genetics in 2020.

Journal of Dermatological Science
Kotaro Ogawa, Yukinori Okada

Abstract

Psoriasis is an immune-mediated disease associated with skin and joint inflammation that affects large proportions of populations worldwide. It is a heritable disease: individuals' genetic backgrounds modulate their susceptibility. In genetics, multiple human leukocyte antigen (HLA) genes are most strongly associated with the risk of psoriasis, especially HLA-C*06:02. In the last 10 years, large-scale genome-wide association studies (GWASs) of psoriasis have been conducted in multiple populations, and these have substantially increased the number of genetic loci associated with psoriasis susceptibility (n > 80). Understanding the genetic background of psoriasis is important for understanding the disease's biology, identifying clinical biomarkers, discovering novel drug targets, and accelerating the journey towards personalized medicine. However, the application of whole-genome and long-read sequencing technology in psoriasis genetic analysis is still developing. Moreover, achieving practical strategies for translating psoriasis risk-associated genetic variants into functional annotations and clinical applications remains challenging. In this review, we detail the current and future landscape of psoriasis genetics and introduce ...Continue Reading

Citations

Jan 10, 2021·Medicina·Ester Muñoz-AceitunoEsteban Daudén
Jan 2, 2021·Journal of Personalized Medicine·Dmitry A VerbenkoAlexey A Kubanov
Mar 16, 2021·Frontiers in Immunology·Hélène Bugaut, Sélim Aractingi
Apr 7, 2021·Immunotherapy·Lilla LandeckKhusru Asadullah
Apr 11, 2021·Journal of Dermatological Science·Toshihiro KishikawaYukinori Okada
May 4, 2021·Molecular Diagnosis & Therapy·Bárbara LealTiago Torres
May 1, 2021·International Journal of Clinical Practice·Teodora-Larisa TimisRemus-Ioan Orasan
Aug 11, 2021·Pharmaceutics·Jen-Chih TsengTsung-Hsien Chuang
Aug 28, 2021·International Journal of Molecular Sciences·Dorota Purzycka-BohdanRoman J Nowicki

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