The current lymphoma classification: new concepts and practical applications triumphs and woes.

Annals of Saudi Medicine
Nasir Bakshi, Irfan Maghfoor

Abstract

The World Health Organization (WHO) classification of lymphomas updated in 2008 represents an international consensus for diagnosis of lymphoid neoplasms based on the recognition of distinct disease entities by applying a constellation of clinical and laboratory features. The 2008 classification has refined and clarified the definitions of well-recognized diseases, identified new entities and variants, and incorporated emerging concepts in the understanding of lymphoid neoplasms. Rather than being a theoretical scheme this classification has used data from published literature. Recent knowledge of molecular pathways has led to identification and development of new diagnostic tools, like gene expression profiling, which could complement existing technologies. However, some questions remain unresolved, such as the extent to which specific genetic or molecular alterations define certain tumors. In general, practical considerations and economics preclude a heavily molecular and genetic approach. The significance of early or precursor lesions and the identification of certain lymphoid neoplasms is less clear at present, but understanding is evolving. The borderline categories having overlapping features with large B-cell lymphomas,...Continue Reading

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Citations

Apr 6, 2016·BMC Cancer·Maryam DelforoushJoachim Gullbo
May 26, 2016·Asian Pacific Journal of Cancer Prevention : APJCP·Dalia Y KadryNadia M Mokhtar

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Methods Mentioned

BETA
chromosomal aberrations
chip

Software Mentioned

GEP
PRIMA

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