The current markers of cancer stem cell in oral cancers

Life Sciences
Elahe TahmasebiAlexander Seifalian

Abstract

Head and neck cancer (HNC) constitute 5% of all reported cancers. Among all, the oral cavity cancer is the most frequent type of HNC which accounts for over half of HNC cases. Mouth cancer ranks the sixth leading cause of cancer-related mortality. Generally, conventional chemotherapy has shown success at decreasing relapse and metastasis rates and improves the overall prognosis. Recently, target therapy and targeted drug delivery systems have been introduced as promising treatments. The elimination of efficiency of current therapeutic strategies due to the spared cancer stem cells that cause chemotherapy resistance, relapse and metastasis. Inefficiency methodologies in the elimination of all cancer cells in the body are a major problem that remained to be resolved before to confront the new cancer therapies. Many studies imply to cancer stem cell markers as important agents for targeted anti-cancer as well as improving chemotherapy efficiencies. The potentials of targeted cancer therapy led us to search for novel markers in the mouth cancer stem cells especially in rare cancers. The aimed of this research was, first a comprehensive critical review of the previous studies on the markers of cancer stem cells in oral cancers inclu...Continue Reading

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Citations

Dec 9, 2020·Chemistry, an Asian Journal·Jiameng WangHongyuan Yan
Jan 27, 2021·Cancers·Faustino Julián Suárez-SánchezJuan Carlos de Vicente
May 1, 2021·Journal of Personalized Medicine·Ming-Hong HsiehShun-Fa Yang

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