PMID: 11605179Oct 18, 2001Paper

The current state of paclitaxel and radiation in the combined-modality therapy of non-small cell lung cancer

Seminars in Oncology
H Choy, R MacRae

Abstract

The results of randomized trials have prompted an evolution in the treatment approach to inoperable locally advanced non-small cell lung cancer, from radiotherapy alone to sequential chemoradiotherapy and now to concurrent chemoradiotherapy. The improvement in outcome seen with a concurrent chemoradiotherapy approach may be because of spatial cooperation, enhanced radiosensitization, and/or enhanced cytotoxicity. The taxanes, specifically paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ), delivered in combination with radiation have been extensively examined in both preclinical and clinical studies. Several mechanisms have been suggested to explain the enhanced tumor cell kill seen with paclitaxel and radiation, and phase II studies have examined this combination in the setting of inoperable stage III non-small cell lung cancer. This review will explore some of the studies with this treatment approach in locally advanced disease. We also will briefly discuss some of the ongoing trials that are attempting to refine the delivery of concurrent thoracic radiation and paclitaxel-based chemotherapy.

Citations

Sep 6, 2003·International Journal of Radiation Oncology, Biology, Physics·Dosia AntonadouMaria Synodinou
May 4, 2004·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·Nadezhda V KoshkinaVernon Knight
Apr 6, 2004·Critical Care Medicine·Charlotte Eielson Ariyan, Julie Ann Sosa
Jul 18, 2006·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Byeong-Bae ParkKeunchil Park
Jan 2, 2003·Head & Neck·Luka MilasKian K Ang
Nov 23, 2006·Lasers in Surgery and Medicine·Patrick RossCynthia Magro
Jul 6, 2004·International Journal of Radiation Oncology, Biology, Physics·Eiko NakataLuka Milas
Jan 23, 2009·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·C ChargariN Magné

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