The current status in hematopoietic stem cell mobilization.

Journal of Clinical Apheresis
Sinem Civriz BozdagFevzi Altuntaş

Abstract

Hemotopoietic stem cell mobilization with cytokines alone, has still been widely accepted as the initial attempt for stem cell mobilization. Chemotherapy based mobilization can be preferred as first choice in high risk patients or for remobilization. But mobilization failure still remains to be a problem in one third of patients. Salvage mobilization strategies have been composed to give one more chance to 'poor mobilizers'. Synergistic effect of a reversible inhibitor of CXCR4, plerixafor, with G-CSF has opened a new era for these patients. Preemptive approach in predicted poor mobilizers, immediate salvage approach for patients with suboptimal mobilization or remobilization approach of plerixafor in failed mobilizers have all been demonstrated convincing results in various studies. Alternative CXCR4 inhibitors, VLA4 inhibitors, bortezomib, parathormone have also been emerged as novel agents for mobilization failure.

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Citations

Jan 27, 2016·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Mehmet Hilmi DoguFevzi Altuntaş
Mar 13, 2016·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Sinem Civriz BozdağFevzi Altuntaş
Dec 15, 2015·Cytometry. Part B, Clinical Cytometry·Thomas R CimatoPaul K Wallace
Jun 14, 2017·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Luca Basso-RicciLuca Biasco
Nov 12, 2015·Current Opinion in Hematology·Yavuz M Bilgin, Georgine E de Greef

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