PMID: 6162368Jan 1, 1980Paper

The current status of analgesic brain stimulation

Acta neurochirurgica. Supplementum
Yoshio Hosobuchi

Abstract

This paper reviews the author's nine years of experience in analgesic brain stimulation. During this time, of 22 patients with pain of peripheral origin who were treated with periaqueductal gray (PAG), stimulation 16 achieved successful control of pain. Of 40 patients who presented with deafferentation pain, 16 were able to control their dysesthesia by brain stimulation of the subcortical somatosensory region alone; follow-up was over a long period. The mechanism of deafferentation pain is poorly understood and the effectiveness of subcortical somatosensory electrical stimulation to relieve such pain is based on empirical observation. The analgesia produced by PAG stimulation appears to be mediated by the release of beta-endorphin from the anterior hypothalamus. The released beta-endorphin binds to the opiate receptors in the PAG and activates the descending pain-inhibitory pathway. However, the repetitive stimulation of this serotonergic system produces tolerance to its analgesic effect, due to a decreased rate of serotonin turnover. Loading of the serotonin precursor by dietary supplementation of the essential amino acid L-tryptophan reverses this tolerance.

Citations

May 8, 2007·European Journal of Applied Physiology·Tamás BenderPál Géher
Feb 5, 2013·Neuromodulation : Journal of the International Neuromodulation Society·Robert M Levy
Jan 1, 1984·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·A Spring
Dec 21, 2006·Pain Practice : the Official Journal of World Institute of Pain·David Niv, Alexander Maltsman-Tseikhin
May 29, 2014·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Erlick A C Pereira, Tipu Z Aziz
May 1, 1986·Pain·J D Loeser
Apr 23, 2004·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·R J Coffey
Dec 13, 2006·Pain Practice : the Official Journal of World Institute of Pain·C Peter N Watson, Anne Louise Oaklander

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