The current understanding of the interactions between nanoparticles and cytochrome P450 enzymes - a literature-based review

Xenobiotica; the Fate of Foreign Compounds in Biological Systems
Yan PanJin Yu Chieng

Abstract

Nanoparticles (NPs) have wide spectrum applications in the areas of industry and biomedicine. However, concerns about their toxic and negative impacts on the environments as well as human health have been raised. Cytochrome P450s (CYPs) are involved in endogenous and exogenous metabolism. Modulations of CYP can adversely damage drug metabolism, detoxification of xenobiotics and animal physiology functions. This article focused on NPs-CYP interactions for humans and animals available in the literature. It was found that different NPs process specific inhibitory potencies against CYPs involved in drug metabolism. Moreover, NPs were able to modify the expression of CYPs genes or protein in humans and other animals, which highlighted their detoxification functions. Nonetheless, changes of CYPs responsible for hormone synthesis and metabolism resulted in endocrine disturbances. Hence, there is a need to screen newly developed NPs to evaluate their interactions with CYPs. The future studies should further strategize the in vitro approaches to reveal the molecular mechanisms behind interactions by taking full considerations of the interference of co-factors, buffers, substrates and metabolites with NPs. Moreover, in vivo studies shoul...Continue Reading

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Citations

Apr 6, 2019·Expert Opinion on Drug Metabolism & Toxicology·Yuqing GongSantosh Kumar
Jun 19, 2019·Nanoscale Research Letters·Kyoungju Choi, Hyun Joo
Dec 15, 2019·Materials·Justyna SekretarskaBarbara Strojny

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