The curse of angiopoietin-2 in ARDS: on stranger TI(E)des

Critical Care : the Official Journal of the Critical Care Forum
Philipp Kümpers, Alexander Lukasz

Abstract

Pulmonary inflammation and vascular leakage are hallmarks of acute respiratory distress syndrome (ARDS), a life-threatening condition, for which there is no specific pharmacologic treatment.Recent literature suggests that leaky vessels in pulmonary infection and ARDS may be mediated through dysregulation of a non-redundant endothelial control pathway, the Tie2 receptor and its ligands, the angiopoietins.This Viewpoint summarizes results from cell-based experiments, animal models and clinical studies underlining the potential of Tie2 targeted interventions in reducing infection-mediated pulmonary hyperpermeability.

References

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Citations

Jan 18, 2019·Respirology : Official Journal of the Asian Pacific Society of Respirology·Camila Barbosa AraújoAlexandre Braga Libório
Aug 8, 2018·Medizinische Klinik, Intensivmedizin und Notfallmedizin·A-H Lukasz, P Kümpers
Nov 30, 2020·The Journal of Clinical Endocrinology and Metabolism·Christopher Edwards
Jun 30, 2021·Angiogenesis·David M SmadjaArjan W Griffioen

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