The customizable e-cigarette resistance influences toxicological outcomes: lung degeneration, inflammation and oxidative stress-induced in a rat model

Toxicological Sciences : an Official Journal of the Society of Toxicology
Silvia CirilloDonatella Canistro

Abstract

Despite the knowledge gap regarding the risk-benefit ratio of the electronic cigarette (e-cig), its use has grown exponentially, even in teenagers. E-cig vapour contains carcinogenic compounds (e.g., formaldehyde, acetaldehyde and acrolein) and free radicals, especially reactive oxygen species (ROS) that cause toxicological effects, including DNA damage. The role of e-cig voltage customization on molecule generation has been reported, but the effects of the resistance on e-cig emissions and toxicity are unknown. Here we show that the manipulation of e-cig resistance influences the carbonyls production from non-nicotine vapour and the oxidative and inflammatory status in a rat model. Fixing the voltage at the conventional 3.5 V, we observed that the amount of the selected aldehydes increased as the resistance decreased from 1.5 to 0.25 Ω. Under these conditions, we exposed Sprague Dawley rats to e-cig aerosol for 28-days, and we studied the pulmonary inflammation, oxidative stress, tissue damage and blood homeostasis. We found a perturbation of the antioxidant and phase-II enzymes, probably related to the increased ROS levels due to the enhanced xanthine oxidase and P450-linked monooxygenases. Furthermore, frames from scanning e...Continue Reading

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Citations

May 21, 2020·International Journal of Molecular Sciences·Hussein TraboulsiCarolyn J Baglole
Jun 6, 2020·The Journal of Physiology·Tim Marczylo
Oct 30, 2020·International Journal of Environmental Research and Public Health·Qutaiba M SalehRisa J Robinson
Mar 16, 2021·Current Addiction Reports·Rachel Keith, Aruni Bhatnagar
Mar 24, 2021·Pharmacology & Therapeutics·Emily BonnerRobyn L Tanguay
May 1, 2021·International Journal of Environmental Research and Public Health·Qutaiba M SalehRisa J Robinson
May 1, 2021·International Journal of Environmental Research and Public Health·Omar Andrés Bravo-GutiérrezGloria Pérez-Rubio
Oct 21, 2020·Redox Biology·Juan WangCharles Ansong
May 27, 2021·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Fabio VivarelliMoreno Paolini
Jul 10, 2021·The International Journal of Biochemistry & Cell Biology·Kielan Darcy McAlindenSukhwinder Singh Sohal
Sep 3, 2020··Elisabetta FalcieriSabrina Burattini

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