The Cw6 and late-cornified envelope genotype plays a significant role in anti-tumor necrosis factor response among psoriatic patients

Pharmacogenetics and Genomics
Ana BatallaPablo Coto-Segura

Abstract

Our aim was to determine whether the HLA-Cw6 and late-cornified envelope (LCE) deletion polymorphisms were related to disease improvement among psoriasis patients treated with anti-tumor necrosis factor (TNF) antibodies. The study included a total of 116 patients. Positive response (68%) was defined as a reduction of at least 75% of the Psoriasis Area and Severity Index (PASI) after 24 weeks of starting the anti-TNF therapy. We found a trend toward a better response among Cw6-positive patients. The frequency of patients who did not reach the PASI75 was higher among the LCE-DD patients (P=0.028; odds ratio=2.45, 95% confidence interval=1.09-5.52). Patients who were Cw6-positive and LCE-I carriers (ID/II) were significantly more likely to reach PASI75 than those who were Cw6-negative and LCE-DD (P=0.034; odds ratio=3.14, 95% confidence interval=1.07-9.24). In conclusion, we found an interaction between the HLA-Cw6 and LCE genotypes on disease improvement among psoriatic patients treated with anti-TNFs.

References

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Citations

Oct 18, 2015·Rheumatic Diseases Clinics of North America·Darren D O'Rielly, Proton Rahman
Aug 27, 2016·The British Journal of Dermatology·J M P A van den ReekE M G J de Jong
Sep 19, 2017·American Journal of Clinical Dermatology·María C Ovejero-BenitoEsteban Daudén
Jun 25, 2017·The British Journal of Dermatology·L J van VugtE M G J de Jong
Jan 23, 2018·Journal of the European Academy of Dermatology and Venereology : JEADV·F AnzengruberA A Navarini
May 1, 2021·Journal of Personalized Medicine·Cristina Membrive JiménezAlberto Jiménez Morales

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Methods Mentioned

BETA
PCR
genotyping

Software Mentioned

SPSS

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