The CXCL8-CXCR1/2 Axis as a Therapeutic Target in Breast Cancer Stem-Like Cells

Frontiers in Oncology
Pier Adelchi Ruffini

Abstract

Cancer stem-like cells (CSC) have been targeted by different strategies over the last decade. This mini review focuses on preclinical and clinical results obtained by interfering with chemokine receptors CXCR1 and CXCR2 in breast cancer. This strategy is currently being tested in a randomized, double blind phase 2 clinical trial.

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Citations

Dec 21, 2019·Human Vaccines & Immunotherapeutics·Manuela Gonzalez-Aparicio, Carlos Alfaro
Jun 26, 2020·Frontiers in Immunology·Dina MoreinAdit Ben-Baruch
Mar 23, 2021·Frontiers in Oncology·Yasser TabanaKhaled H Barakat
Mar 30, 2021·Frontiers in Cell and Developmental Biology·Laura MosteoDaniel H Wiseman
May 1, 2021·Journal of Clinical Medicine·Elisa Stellaria GrassiLuca Persani
May 8, 2021·Cancer Metastasis Reviews·Sugandha Saxena, Rakesh K Singh
Jul 9, 2021·Frontiers in Cell and Developmental Biology·Martina Mang Leng Lei, Terence Kin Wah Lee
Apr 22, 2021·American Journal of Respiratory and Critical Care Medicine·Roya Babaei-JadidiSimon R Johnson

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Methods Mentioned

BETA
xenografts
biopsies
flow cytometry

Clinical Trials Mentioned

NCT02001974
NCT01861054
NCT02370238

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