The Cyanthin Diterpenoid and Sesterterpene Constituents of Hericium erinaceus Mycelium Ameliorate Alzheimer's Disease-Related Pathologies in APP/PS1 Transgenic Mice

International Journal of Molecular Sciences
Tsai-Teng TzengYoung-Ji Shiao

Abstract

Hericium erinaceus was used in traditional Chinese medicine for physiologically beneficial medicines. Recently, it has become a candidate in causing positive brain health-related activities. We previously reported that Hericium erinaceus mycelium ameliorates Alzheimer's disease (AD)-related pathologies. To reveal the role of the cyanthin diterpenoid and sesterterpene constituents on this effects, erinacine A and S were isolated and their effects on attenuating AD-related pathology in APPswe/PS1dE9 transgenic mice were investigated. A 30 day short-term administration of erinacine A and S were performed to explore the effect of each erinacine on AD-related pathology including amyloid β production and degradation, plaque formation, plaque growth, glial activation and neurogenesis deterioration. Our results indicated the benefit effects of both erinacine A and S in cerebrum of APPswe/PS1dE9 mice, including: (1) attenuating cerebral plaque loading by inhibiting plaque growth; (2) diminishing the activation of glial cells; (3) raising the level of insulin degrading enzyme; and (4) promoting hippocampal neurogenesis. Moreover, erinacine A reduced the level of insoluble amyloid β and C-terminal fragment of amyloid precursor protein whi...Continue Reading

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Citations

Apr 27, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jun-Hao HuChia-Feng Kuo
Jun 29, 2018·Behavioural Neurology·I-Chen LiChin-Chu Chen
May 1, 2021·Biomolecules·Julie GregoryRammohan V Rao
May 15, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Wei-Hsiang HsuYun-Lian Lin

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA
transgenic
NMR
confocal microscopy
electrophoresis

Software Mentioned

GraphPad Prism
ImageJ
Ethovision

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