PMID: 9552396Jan 1, 1996Paper

The cyclin C/Cdk8 kinase

Progress in Cell Cycle Research
V Leclerc, P Léopold

Abstract

Cyclin C was originally identified in a genetic screen for metazoan cDNAs that complement a triple knock-out of the CLN genes, involved in G1/S progression in S. cerevisiae. Unlike cyclin Ds and cyclin E, also identified in this screen, cyclin C has not been found to have a cell-cycle role in metazoa. Identified as the catalytic partner of cyclin C, Cdk8 is a novel protein-kinase of the Cdk family structurally related to the yeast Srb10 kinase. Cyclin C, Cdk8 and RNA polymerase II are found in a large multi-protein complex that shows structural as well as functional homologies with the yeast polymerase II holoenzyme. These observations and the sequence similarity to the kinase/cyclin pair Srb10/Srb11 in S. cerevisiae, suggest that cyclin C and Cdk8 control RNA polymerase II function.

Citations

Jan 17, 2004·The European Journal of Neuroscience·Sarit Edelheit, Noam Meiri
Jan 24, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Donald MassaroLinda Biadasz Clerch
Aug 15, 2012·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Melissa D Lehti-Shiu, Shin-Han Shiu
Oct 29, 2014·Cancers·Jonas CicenasMindaugas Valius
Jun 16, 2004·Developmental Biology·Hsiu-Hsu Sophia LinCatherine Pears
Nov 3, 2006·Developmental Biology·Antonio Fernandez-GuerraAnne-Marie Genevière

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