The cystic fibrosis transmembrane conductance regulator as a biomarker in non-small cell lung cancer

International Journal of Oncology
Jin LiH C Chan

Abstract

An increased risk of non-small cell lung cancer (NSCLC) in cystic fibrosis (CF) patients and carriers of CF transmembrane conductance regulator (CFTR) mutations has been proposed. However, the role of CFTR in lung cancer remains controversial. In the present study, CFTR expression was assessed in 165 NSCLC tumors and 22 normal lung samples with validation in an independent series of 131 samples. The effect of gain and loss of CFTR on the malignant behavior of NSCLC was examined. The effect of CFTR manipulation on tumor metastasis was examined in a mouse model. Expression of CFTR was downregulated in NSCLC (p=0.041). Low CFTR expression was correlated with advanced stage (p<0.001) and lymph node metastasis (p=0.009). Low CFTR expression was significantly associated with poor prognosis (overall survival: 45 vs. 36 months, p<0.0001; progression-free survival: 41 vs. 30 months, p=0.007). Knockdown of CFTR in NSCLC cells enhanced malignant behavior (epithelial-mesenchymal transition, invasion and migration); in contrast, overexpression of CFTR suppressed cancer progression in vitro and in vivo. The tumor-suppressing effect of CFTR was associated with inhibition of multiple uPA/uPAR-mediated malignant traits in culture. These results...Continue Reading

References

Feb 23, 1995·The New England Journal of Medicine·J P NegliaA B Lowenfels
Feb 7, 2002·The European Respiratory Journal·E BrambillaY Shimosato
Jul 22, 2004·Experimental Cell Research·Kathryn L HoweDerek M McKay
Sep 14, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Virginie Prulière-EscabasseAndré Coste
Nov 5, 2004·World Journal of Gastroenterology : WJG·Sheng DingJing-De Zhu
May 25, 2005·Cancer·Robert R McWilliamsGloria M Petersen
Jan 30, 2009·The Journal of Investigative Dermatology·Michael P O'ConnellAshani T Weeraratna
Jan 31, 2009·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Chun-Ru Chien, Tony Hsiu-Hsi Chen
Feb 28, 2009·PloS One·Neeraj VijPamela L Zeitlin
Dec 23, 2009·Nature Reviews. Molecular Cell Biology·Harvey W Smith, Chris J Marshall
Jan 8, 2010·Molecular Cancer Therapeutics·Dhruva Kumar MishraJaydutt V Vadgama
Feb 2, 2010·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Yafei LiPing Yang
Feb 25, 2010·Annals of Surgical Oncology·Stephen B Edge, Carolyn C Compton
May 11, 2010·Cold Spring Harbor Perspectives in Biology·Ranjan Sen, Stephen T Smale
May 12, 2010·Cold Spring Harbor Perspectives in Biology·Toby Lawrence
Jul 2, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Janakiraman SubramanianRamaswamy Govindan
May 19, 2011·Respirology : Official Journal of the Asian Pacific Society of Respirology·Ji Woong SonDong Sun Kim
Nov 4, 2011·The New England Journal of Medicine·Bonnie W RamseyUNKNOWN VX08-770-102 Study Group
Feb 14, 2012·Nature Medicine·Doron LipsonPhilip J Stephens
Feb 14, 2012·Nature Medicine·Kengo TakeuchiYuichi Ishikawa
Feb 14, 2012·Nature Medicine·Takashi KohnoTatsuhiro Shibata
Sep 18, 2012·Cell·Ramaswamy GovindanRichard K Wilson
Nov 28, 2012·Journal of the National Cancer Institute·Patrick MaisonneuveAlbert B Lowenfels
Jan 1, 2014·Biochimica Et Biophysica Acta·Ting Ting SunHsiao Chang Chan

❮ Previous
Next ❯

Citations

Feb 8, 2018·Cellular and Molecular Life Sciences : CMLS·Jieting ZhangHsiao Chang Chan
Aug 18, 2017·United European Gastroenterology Journal·Meike HohwielerAlexander Kleger
Feb 16, 2019·Respiratory Research·Valentino BezzerriMarco Cipolli
Apr 25, 2020·International Journal of Molecular Sciences·Patricia ScottRobert Cormier
Oct 23, 2019·World Journal of Gastroenterology : WJG·Kyle J AndersonPatricia M Scott
May 6, 2020·International Journal of Molecular Sciences·Margarida D AmaralInes Pankonien
Oct 30, 2020·Respiratory Medicine Case Reports·Vipul PatelThomas Kaleekal
Oct 28, 2020·Cell Death & Disease·Margarida C QuaresmaMargarida D Amaral
Mar 13, 2021·Annals of Surgical Oncology·Yoshihisa MatsumotoEigo Otsuji
May 4, 2021·Frontiers in Pharmacology·Lisa KünziStefanie Krick
Jul 24, 2018·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Iikki DonnerLauri A Aaltonen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.