The cytochemical localization of adenyl cyclase activity in rat sublingual gland

The American Journal of Anatomy
S K Kim, S S Han

Abstract

Adenyl cyclase activity in mucous acinar cells and serous demilune cells of the rat sublingual gland was localized cytochemically. After incubation with adenylyl-imidodiphosphate (AMP-PNP) as substrate, deposits of reaction product are found along the cell membranes bordering the secretory surfaces of serous demilune cells. These are the membranes which participate directly in secretion by fusing with the granule membranes. The granule membranes of the demilune cells do not reveal reaction product, but the membranes of the granules which are fused with and become part of the cell membrane do show deposits. Thus, it appears that the cell membranes which fuse with granule membranes during secretion are associated with a high level of adenyl cyclase activity. In support of this, the luminal membranes of the mucous acinar cells which do not fuse with granule membranes during secretion are not associated with detectable amounts of adenyl cyclase activity.

References

Nov 1, 1972·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S L Howell, M Whitfield
Jan 1, 1966·The Anatomical Record·J A Freeman
Apr 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·H Rasmussen, A Tenenhouse
Jan 1, 1968·Annual Review of Biochemistry·G A RobisonE W Sutherland
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Mar 30, 1963·Annals of the New York Academy of Sciences·K H HOLLMANN
Feb 3, 1965·Biochemical and Biophysical Research Communications·A BDOLAH, M SCHRAMM

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Citations

Apr 27, 1977·Archives of Dermatological Research·J SøndergaardT Kobayasi
May 1, 1978·Biological Reviews of the Cambridge Philosophical Society·R M Case
Jan 1, 1984·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·P C MollerL R Partridge
Dec 1, 1978·Experimental Parasitology·P B Conway-Jones, A H Rothman
Feb 1, 1977·The Anatomical Record·B Tandler, J H Poulsen

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