PMID: 2159421Apr 24, 1990

The cytochrome b of the sea urchin Paracentrotus lividus is naturally resistant to myxothiazol and mucidin

FEBS Letters
M Degli EspostiP Cantatore

Abstract

The ubiquinol:cytochrome c reductase activity of Paracentrotus lividus mitochondria is relatively insensitive to the specific inhibitors myxothiazol and mucidin. The I50 of myxothiazol and mucidin are three and two orders of magnitude higher, respectively, in P. lividus than in bovine heart mitochondria. The natural resistance of the P. lividus reductase to these inhibitors can be correlated with a single amino replacement, an alanine for a glycine at position 143, in the sequence of cytochrome b. This position is located in a conserved region of the molecule, believed to be important in the oxidation of ubiquinol by the reductase.

References

Apr 1, 1988·Journal of Bioenergetics and Biomembranes·G HauskaR G Herrmann
Jan 1, 1986·Methods in Enzymology·G Von Jagow, T A Link
Jun 1, 1986·Journal of Bioenergetics and Biomembranes·P R Rich
Jul 20, 1988·Journal of Molecular Biology·H T JacobsA Farquharson
Oct 5, 1988·Journal of Molecular Biology·N Howell, K Gilbert
Jun 1, 1974·Cell Differentiation·P CantatoreC Saccone

Citations

Oct 1, 1992·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·A GhelliM Degli Esposti
Jun 3, 2000·Annual Review of Pharmacology and Toxicology·K B Wallace, A A Starkov
Jul 26, 1993·Biochimica Et Biophysica Acta·M D EspostiA Meyer
May 15, 1992·Archives of Biochemistry and Biophysics·M Degli EspostiA Meyer
Apr 21, 2007·Methods in Cell Biology·Francesco Pallotti, G Lenaz

Related Concepts

Mucidermin
Myxothiazol
Strobilurins
Pentenes
Metazoa
Bos indicus
Fatty Acids, Unsaturated
Methacrylates
Mitochondria
Mitochondria, Heart

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