The cytochromes P450 and mechanisms of chemical carcinogenesis

Environmental Health Perspectives
D V Parke

Abstract

This article reviews mechanisms of chemical carcinogenesis, from metabolic activation and generation of reactive oxygen species by cytochromes P4511 and P4502E to DNA damage, activation of protein kinase C and ocogenes, hyperplasia, and proteoglycan changes in the cell glycocalyx and lysosomal enzymes which mediate invasion and metastasis.

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Citations

Dec 1, 1996·Environmental Health Perspectives·D V Parke
Oct 2, 1998·Environmental Health Perspectives·D F LewisD V Parke
Feb 7, 2008·Archives of Toxicology·Jihei NishimuraKunitoshi Mitsumori
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Feb 8, 2011·Toxicology and Applied Pharmacology·James E KlaunigShaoyu Zhou
Mar 14, 2008·Chemico-biological Interactions·Periasamy SrinivasanChennam Srinivasulu Shyamala Devi
Mar 19, 2014·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Hassan R Dhaini, Loulou Kobeissi
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Dec 30, 2020·Biomolecules·Clémence RivesWalter Wahli
Aug 12, 1996·Mutation Research·D F Lewis, G R Langley

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