The Cytokine TGF-β Induces Interleukin-31 Expression from Dermal Dendritic Cells to Activate Sensory Neurons and Stimulate Wound Itching.

Immunity
Junji XuWanJun Chen

Abstract

Cutaneous wound healing is associated with the unpleasant sensation of itching. Here we investigated the mechanisms underlying this type of itch, focusing on the contribution of soluble factors released during healing. We found high amounts of interleukin 31 (IL-31) in skin wound tissue during the peak of itch responses. Il31-/- mice lacked wound-induced itch responses. IL-31 was released by dermal conventional type 2 dendritic cells (cDC2s) recruited to wounds and increased itch sensory neuron sensitivity. Transfer of cDC2s isolated from late-stage wounds into healthy skin was sufficient to induce itching in a manner dependent on IL-31 expression. Addition of the cytokine TGF-β1, which promotes wound healing, to dermal DCs in vitro was sufficient to induce Il31 expression, and Tgfbr1f/f CD11c-Cre mice exhibited reduced scratching and decreased Il31 expression in wounds in vivo. Thus, cDC2s promote itching during skin would healing via a TGF-β-IL-31 axis with implications for treatment of wound itching.

Associated Datasets

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Citations

Mar 2, 2021·Frontiers in Medicine·Kenji Kabashima, Hiroyuki Irie
Mar 3, 2021·Nature Reviews. Immunology·Andrea Francesca SalvadorJonathan Kipnis
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Myun Soo KimDaeho Cho
Feb 26, 2021·Allergy·Angeliki DatsiJoerg Buddenkotte
Apr 6, 2021·Frontiers in Immunology·Dan J K YomboSatish K Madala
Apr 6, 2021·The Journal of Allergy and Clinical Immunology·Yasuhisa KamikasedaYoshinori Fukui
Jan 23, 2021·Annual Review of Immunology·Mar Cabeza-CabrerizoCaetano Reis E Sousa
May 1, 2021·Journal of Clinical Medicine·Masutaka Furue, Mihoko Furue
May 4, 2021·Frontiers in Immunology·Joshua R CoxAmy E Saunders
Aug 20, 2020·Immunity·Ting-Lin B Yang, Brian S Kim
Oct 7, 2021·International Immunology·Hiroyuki Irie, Kenji Kabashima
Sep 15, 2021·Acta Dermato-venereologica·Ahmed A HawashGil Yosipovitch
Nov 11, 2021·Science Translational Medicine·Pang-Yen Tseng, Mark A Hoon

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Datasets Mentioned

BETA
GM-CSF

Methods Mentioned

BETA
RNA-seq
ELISA
PCR
flow cytometry
FCS
FACS

Software Mentioned

NIH ImageJ
R
GraphPad Prism
DESeq
FlowJo

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