The Cytolethal Distending Toxin Subunit CdtB of Helicobacter Induces a Th17-related and Antimicrobial Signature in Intestinal and Hepatic Cells In Vitro

The Journal of Infectious Diseases
Christelle Péré-VédrenneA Ménard

Abstract

Enterohepatic Helicobacter species are associated with several digestive diseases. Helicobacter pullorum is an emerging human foodborne pathogen, and Helicobacter hepaticus is a mouse pathogen; both species are associated with intestinal and/or hepatic diseases. They possess virulence factors, such as cytolethal distending toxin (CDT). Data indicate that CDT may be involved in chronic inflammatory responses, via its active subunit, CdtB. The proinflammatory properties of the CdtB of H. pullorum and H. hepaticus were assessed on human intestinal and hepatic epithelial cells in vitro. Interleukin 8 expression was evaluated by using wild-type strains and their corresponding CdtB isogenic mutants and by delivering CdtB directly into the cells. Nuclear factor κB nuclear translocation and transcriptomic characteristics in response to CdtB were also evaluated. The CdtB of these Helicobacter species induced nuclear factor κB nuclear translocation and exhibited proinflammatory properties, mainly the expression of T-helper type 17-related genes and genes encoding antimicrobial products also involved in cancer. The Histidine residue in position 265 of the CdtB catalytic site appeared to play a role in the regulation of most of these genes...Continue Reading

References

Jan 1, 1992·International Journal of Clinical & Laboratory Research·K SakamotoM Ogawa
Jan 1, 1997·Scandinavian Journal of Infectious Diseases·B SteinbruecknerM Kist
Jul 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·A M ColeR M Strieter
Apr 23, 2004·Infection and Immunity·Vincent B YoungDavid B Schauer
May 18, 2004·Biochemical and Biophysical Research Communications·Philippe AvenaudArmelle Ménard
Jun 9, 2004·Journal of Clinical Microbiology·Ulrich R M BohrPeter Malfertheiner
Jul 19, 2006·Biochemical Pharmacology·Christoffer GebhardtJochen Hess
Oct 13, 2006·The Journal of Experimental Medicine·Marika C KullbergAlan Sher
Aug 7, 2007·Nature Medicine·Kenshi YamasakiRichard L Gallo
Mar 21, 2008·The Lancet Infectious Diseases·Rinaldo PellicanoFrancis Mégraud
Oct 25, 2008·Nature Reviews. Immunology·Jay K KollsYvonne R Chan
Aug 5, 2009·Journal of Cellular and Molecular Medicine·Hana BlazkovaJiri Bartek
Dec 14, 2011·Cancer Research·Mohd W NasserRamesh K Ganju
Jul 20, 2012·International Journal of Inflammation·B MeijerA S Day
Jul 28, 2012·Current Molecular Medicine·R DonatoC L Geczy
Oct 17, 2012·Helicobacter·Emilie Le Roux-GoglinFrancis Mégraud
Mar 7, 2013·Mucosal Immunology·P J MorrisonM C Kullberg
May 15, 2013·Current Opinion in Pharmacology·Eva HattingerRonald Wolf
Nov 21, 2013·Experimental and Therapeutic Medicine·Bin LiuHai-Cheng Gao
Apr 9, 2014·Cells·Georgios N Belibasakis, Nagihan Bostanci

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Citations

Aug 18, 2016·Helicobacter·Chloë De WitteFreddy Haesebrouck
Jan 13, 2018·Frontiers in Microbiology·Nathalie L van der Mee-MarquetPatrice François
Dec 21, 2016·Frontiers in Cellular and Infection Microbiology·Monika D ScuronBruce J Shenker
Oct 23, 2019·Signal Transduction and Targeted Therapy·Ziying ZhangYongguang Tao
Sep 2, 2020·International Journal of Molecular Sciences·Carla FiorentiniAlessia Fabbri
Oct 11, 2020·Signal Transduction and Targeted Therapy·Ziying ZhangYongguang Tao
Jul 27, 2021·Cellular and Molecular Life Sciences : CMLS·Benoît J PonsJulien Vignard
Aug 24, 2021·Seminars in Cancer Biology·Christine VaronPirjo Spuul

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