PMID: 6408498Apr 1, 1983Paper

The cytology of dopaminergic and nondopaminergic neurons in the substantia nigra and ventral tegmental area of the rat: a light- and electron-microscopic study

Neuroscience
V B DomesickP A Paskevich

Abstract

The results of this study support the conclusion that dopaminergic cells can be distinguished from non-dopaminergic cells, at both the light- and electron-microscopic level, by cytological features, and particularly by the pattern of Nissl substance. In both the substantia nigra and the ventral tegmental area, two main categories of cell type can be identified in Nissl preparations: (1) dark-staining, basophilic cells with large masses of Nissl substance and (2) light-staining cells with more translucent cytoplasm. The following findings provide evidence that the basophilic cells of both substantia nigra and ventral tegmental area are the dopaminergic cells. (1) There is a good correlation between the topographic distribution of basophilic cells and that of dopaminergic cells mapped by both histofluorescence and immunohistochemical methods. (2) After unilateral destruction of the dopaminergic neurons by intracerebral injection of 6-hydroxydopamine in the dopaminergic pathway, the basophilic cells in the substantia nigra and ventral tegmental area disappeared on the lesion side, while the lighter-staining cells appeared unaffected. (3) In normal rats, and in rats with unilateral 6-hydroxydopamine lesions, intraventricular inject...Continue Reading

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Citations

Mar 24, 1997·The Journal of Comparative Neurology·S BischoffS Heinemann
Apr 13, 2006·Acta Neuropathologica·Kazuhiko NakadateShuichi Ueda
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Sep 15, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Prasannakumar DeshpandeEleanor T Coffey

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