The cytolytic toxin aerolysin: from the soluble form to the transmembrane channel

Toxicology
F G van der GootJ T Buckley

Abstract

Aerolysin is a cytolytic toxin which forms channels in the plasma membranes of eucaryotic cells. The protein is secreted by Aeromonas hydrophila as an inactive protoxin. Its stability and water solubility are conferred by its ability to dimerize. Maturation of the protein occurs through proteolytic removal of a C-terminal peptide outside the secreting cell. Although the aerolysin which is so produced is still a dimer, it then has the ability to oligomerize. The oligomer is the active form of the toxin, capable of forming the transmembrane channels that disrupt cells. We review here the present knowledge about the structure of aerolysin in relation to the various steps in channel formation.

References

Jun 1, 1975·Infection and Immunity·A W BernheimerG Avigad
Jan 1, 1990·Toxicon : Official Journal of the International Society on Toxinology·G MenestrinaC A Pasternak
Aug 1, 1991·Current Opinion in Cell Biology·M C Peitsch, J Tschopp
Dec 1, 1991·Microbiological Reviews·S Bhakdi, J Tranum-Jensen
Mar 28, 1991·European Journal of Biochemistry·J H LakeyF Pattus
Jul 31, 1990·Biochemistry·M S Gittelman, C R Matthews
Apr 20, 1990·Journal of Molecular Biology·A D TuckerJ T Buckley
Sep 5, 1989·Biochemistry·J U Bowie, R T Sauer
Jul 1, 1985·Journal of Bacteriology·S P Howard, J T Buckley
Apr 1, 1981·Journal of Clinical Microbiology·O P DailyC R Lissner
Nov 1, 1992·Trends in Cell Biology·F G van der GootF Pattus

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Citations

Nov 25, 2004·Progress in Biophysics and Molecular Biology·Michael W Parker, Susanne C Feil
Feb 1, 1996·Biophysical Journal·M Tschödrich-RotterR Peters
Aug 1, 1997·Current Opinion in Structural Biology·E Gouaux
Dec 1, 1995·Australian and New Zealand Journal of Medicine·M W Parker
Jun 4, 2014·Mediators of Inflammation·Abdelaziz S A AbuelsaadAdnan A A Al-Solumani
Jun 6, 2009·Biochemical and Biophysical Research Communications·Nicole KloftMatthias Husmann
Oct 26, 2010·Journal of Biochemistry·Hiroyasu Shimada, Sakae Kitada
Jan 7, 2017·Mutagenesis·Benjamin J ReesGeorge E Johnson
Apr 12, 1996·The Journal of Biological Chemistry·B Vécsey-SemjénF G van der Goot
Nov 5, 1997·Microbial Pathogenesis·T C BarnettK Sanderson
Mar 1, 1996·Microbiological Reviews·C L Sears, J B Kaper
Jan 31, 2018·ACS Sensors·Haiyan WangJohn J Kasianowicz

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