The cytoplasmic tail of the mouse brown locus product determines intracellular stability and export from the endoplasmic reticulum

The Journal of Investigative Dermatology
Y XuA N Houghton

Abstract

Several melanosome membrane proteins have been identified, forming a family of proteins known as tyrosinase related proteins. Human TRP-1/gp75 is sorted to melanosomes through the endoplasmic reticulum and Golgi complex to the endocytic pathway, directed by a sorting signal located in the cytoplasmic tail. This hexapeptide cytoplasmic sequence, which is conserved in the tyrosinase related protein family and through vertebrate evolution, was shown to act also as a sorting signal in mouse gp75, confirming that its sorting and cellular retention function is conserved between human and mouse. The cytoplasmic tail influenced the rate and efficiency of intracellular transport of gp75 from the endoplasmic reticulum to the cis-Golgi. Deletion of 33 or 27 amino acids from the carboxyl end of the 38 amino acid cytoplasmic tail of gp75 caused retention and rapid degradation of the truncated gp75 in the endoplasmic reticulum. This defective movement could be fully corrected by extending the truncated tail with the unrelated cytoplasmic tail of the low density lipoprotein receptor. Thus, the cytoplasmic tail of mouse gp75 not only determines sorting to the endocytic/melanosomal compartment, but also controls export from the endoplasmic reti...Continue Reading

References

Jan 21, 1991·International Journal of Cancer. Journal International Du Cancer·S Vijayasaradhi, A N Houghton
Aug 24, 1990·Cell·R D Klausner, R Sitia
Apr 1, 1990·The Journal of Experimental Medicine·S VijayasaradhiA N Houghton
Jun 1, 1989·The Journal of Experimental Medicine·B BouchardA N Houghton
Jun 1, 1989·The Journal of Cell Biology·S M HurtleyC S Copeland
Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·B S KwonR Halaban
Mar 25, 1986·Nucleic Acids Research·S ShibaharaR Müller
Jan 1, 1988·Annual Review of Cell Biology·J K Rose, R W Doms
Mar 1, 1987·The Journal of Experimental Medicine·A N HoughtonL J Old
Jun 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·I J Jackson
Dec 15, 1983·International Journal of Cancer. Journal International Du Cancer·M J MattesK O Lloyd
May 5, 1995·Cell·K Fiedler, K Simons
Sep 27, 1994·Proceedings of the National Academy of Sciences of the United States of America·S L TopalianS A Rosenberg
Jul 1, 1994·The Journal of Experimental Medicine·A N Houghton
Jun 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·M Mizuno, S J Singer
Mar 1, 1996·The Journal of Experimental Medicine·R F WangS A Rosenberg
Dec 10, 1996·Proceedings of the National Academy of Sciences of the United States of America·C NaftzgerA N Houghton
Dec 24, 1997·The Journal of Investigative Dermatology·Y XuA N Houghton

❮ Previous
Next ❯

Citations

Aug 3, 1999·The Journal of Experimental Medicine·U V WesleyA N Houghton
Apr 9, 2009·Cancer Research·Fei DuanAlan N Houghton
Apr 15, 2006·The Journal of Clinical Investigation·José A Guevara-PatiñoAlan N Houghton
Jun 12, 2016·Chemico-biological Interactions·Eunsun JungJongsung Lee
Jan 18, 2020·Oxidative Medicine and Cellular Longevity·Young Sun HwangJongsung Lee
Aug 15, 2001·Laboratory Investigation; a Journal of Technical Methods and Pathology·R van den WijngaardP Das
Sep 3, 2020·Molecular Therapy : the Journal of the American Society of Gene Therapy·Amanda L HuffRichard Vile

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.