PMID: 18414027Apr 17, 2008Paper

The cytoprotective Nrf2 transcription factor controls insulin receptor signaling in the regenerating liver

Cell Cycle
Tobias A Beyer, Sabine Werner

Abstract

The Nrf2 transcription factor is a crucial regulator of the cellular redox homeostasis through its capacity to induce the expression of enzymes, which detoxify reactive oxygen species, and of other antioxidant proteins. Therefore, it plays an important role in the protection from carcinogenesis induced by various insults. In addition, recent results identified a novel role of Nrf2 in tissue repair. In the liver, regeneration after partial hepatectomy was strongly delayed in the absence of Nrf2. This defect was shown to result from transient resistance to insulin and insulin-like growth factor 1 that was caused by chronic oxidative stress in hepatocytes. These results demonstrate a link between Nrf2 deficiency, oxidative stress and insulin resistance, and suggest that activation of this transcription factor could be a novel strategy to improve liver regeneration in patients with acute or chronic liver injury. In addition, it may help to alleviate oxidative stress-induced insulin resistance in the liver and potentially also in other organs.

Citations

Jan 31, 2009·Cardiovascular Research·Ling Gao, Giovanni E Mann
Jul 16, 2010·Science Signaling·Nobunao WakabayashiThomas W Kensler
Oct 25, 2012·International Journal of Hepatology·Julie PajaudCaroline Aninat
Mar 10, 2016·Oxidative Medicine and Cellular Longevity·Regina MedvedevEberhard Hildt
Aug 17, 2010·Free Radical Biology & Medicine·Adeel SafdarMark A Tarnopolsky
Sep 1, 2011·Molecular and Cellular Endocrinology·Xin WangChun X Hai
Oct 23, 2012·Free Radical Biology & Medicine·Tapasi RanaSwati Biswas
May 9, 2016·Cellular and Molecular Life Sciences : CMLS·Sebastian Robert BarthelEberhard Hildt
Apr 5, 2016·Free Radical Research·Lei JiangNing Tan
Jun 21, 2018·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·William C BuhrmanDionisios Vrochides
Dec 4, 2013·Molecular and Cellular Biology·Nobunao WakabayashiThomas W Kensler
Oct 23, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kyeong-Ah Jung, Mi-Kyoung Kwak
Feb 26, 2019·Journal of Surgical Oncology·Ryan W Day, Thomas A Aloia
Nov 2, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·Xiang DingGavin E Arteel
Sep 25, 2019·International Journal of Molecular Sciences·Daniela Bender, Eberhard Hildt
Jun 21, 2019·Journal of Applied Toxicology : JAT·Nan ZhengLili Wang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.