PMID: 2478832Jan 1, 1989Paper

The cytoskeleton of arterial smooth muscle cells during development, atheromatosis, and tissue culture.

Journal of Cardiovascular Pharmacology
L Rubbia, G Gabbiani

Abstract

Arterial smooth muscle cells (SMCs) assume cytoskeletal features of embryonic cells during human and experimental atheromatosis, as well as when placed in culture. The expression of alpha-smooth muscle (SM) actin can be used to monitor these changes. The synthesis of alpha-SM actin is decreased early after plating in cultured cells and early after endothelial lesion in animals. The amount of mRNA for alpha-SM actin is not affected in cultured cells, although it is drastically decreased in the carotid artery after endothelial injury. Heparin does not modify in vivo the early decrease of alpha-SM actin mRNA and synthesis, but, by inhibiting the entry of SMC into the S phase of the cell cycle, it produces an early reinduction of alpha-SM actin.

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