The cytosolic aldehyde dehydrogenase gene (Aldh1) is developmentally expressed in Leydig cells

FEBS Letters
L A López-Fernández, J del Mazo

Abstract

Cytosolic aldehyde dehydrogenase, ALDH1, participates in the oxidation of different aldehydes including that of all-trans retinal to retinoic acid. The accumulation of mouse Aldh1 transcripts is characterized by having different patterns in different tissues. This paper reports the greatest expression of Aldh1 in testis and liver. It was demonstrated that in testis, Aldh1 is specifically expressed in Leydig cells and is under developmental regulation. In vitro studies of cultured Leydig TM3 cells confirmed these results though such gene expression was found not to be mediated by LH regulation. Previous investigations have associated androgen receptors, and hence the androgen insensitivity syndrome in man, with the presence of ALDH1 in genital skin fibroblasts. However, this relationship was not established in a functional cell type, as is reported here for Leydig cells. These results could suggest a model for a molecular pathway from androgen receptor to retinoic acid biogenesis in Leydig cells via the mediation of ALDH.

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Citations

Jul 9, 2004·Cytogenetic and Genome Research·S S W Chung, D J Wolgemuth
Feb 1, 2011·Trends in Endocrinology and Metabolism : TEM·Cathryn A HogarthMichael D Griswold
Jul 21, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Josephine BowlesPeter Koopman
May 20, 2003·Biochemical Pharmacology·Isabelle GagnonPangala V Bhat
Jan 24, 2002·Mechanisms of Development·L A López-FernándezJ del Mazo
May 31, 2011·Biochimica Et Biophysica Acta·Joseph L Napoli
Feb 12, 2009·Biology of Reproduction·Akihiro KawashimaNaomichi Okamura
Nov 8, 2013·Biology of Reproduction·Mito Kanatsu-ShinoharaTakashi Shinohara
Aug 9, 2017·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Denis PavălEleonora Dronca
Aug 16, 2019·Sexual Development : Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation·Verónica Díaz-HernándezHoracio Merchant-Larios

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