PMID: 2505792Mar 1, 1989Paper

The cytostatic effects of alpha-interferon may be mediated by transforming growth factor-beta

Journal of Molecular Endocrinology
D J KerrR E Leake

Abstract

There is some evidence to suggest that transforming growth factor-beta (TGF-beta) mediates the cytostatic effects of the anti-oestrogen tamoxifen. In this study we have demonstrated that alpha-interferon has a significant anti-proliferative effect on the oestrogen receptor-positive human breast cancer cell line ZR-75. There is decreased phenotypic expression of the oestrogen receptors (to about 30% of control values) and increased TGF-beta mRNA. Under the growth conditions used here, ZR-75 cells had approximately 5800 TGF-beta binding sites per cell, with an apparent dissociation constant of 70 pm, and we have shown that the anti-proliferative effects of alpha-interferon can be reduced by 60% by co-treating the cells with a TGF-beta polyclonal antibody. The cytostatic effects of alpha-interferon may therefore be mediated by TGF-beta in this human breast cancer cell line.

Citations

Mar 1, 1997·Trends in Neurosciences·T Schimmang, J Represa
Feb 25, 1998·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·F RecchiaG Sica
May 2, 1997·International Journal of Cancer. Journal International Du Cancer·D J Lindner, E C Borden
Jan 1, 1991·Annals of the New York Academy of Sciences·R LeakeF Rinaldi
Jan 1, 1990·Annals of the New York Academy of Sciences·R LeakeF Rinaldi
May 1, 1992·The Journal of Urology·S J HawkyardG D Chisholm
Apr 15, 1994·International Journal of Cancer. Journal International Du Cancer·G ScambiaS Mancuso
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G SicaA Zaniboni

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