PMID: 15384204Sep 24, 2004Paper

The cytotoxic activity of lactoperoxidase: enhancement and inhibition by neuroactive compounds

Free Radical Biology & Medicine
J Everse, Penelope W Coates

Abstract

Neuronal death associated with Parkinson's disease is commonly believed to be caused by oxygen- and nitrogen-derived free radical species. Some years ago, however, we showed that peroxidase from the midbrain of dogs is able to kill various cell types, including neuroblastoma cells (M. B. Grisham et al., J. Neurochem. 48: 876-882: 1987). We postulated that a nigral peroxidase may play a significant role in the degeneration of dopaminergic neurons in Parkinson's disease. To further establish proof of principle, we recently performed a series of experiments using horseradish peroxidase and lactoperoxidase. We showed that the cytotoxic activity of lactoperoxidase is fully inhibited by physiological concentrations of dopamine, reduced glutathione, and L-cysteine, as well as by micromolar concentrations of apomorphine, desferal, aspirin, and uric acid. l-Methyl-4-phenyl-1,2-dihydropyridine (MPDP) and l-methyl-4-phenylpyridinium (MPP+) augment the cytotoxic activity, whereas l-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, deprenyl, and pargyline had minimal or no effect. We also showed that horseradish peroxidase catalyzes the oxidation of MPDP to MPP+. Thus, contrary to the generally accepted theory that the in vivo oxidation of MPDP o...Continue Reading

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Citations

Apr 28, 2005·Free Radical Biology & Medicine·Johannes Everse, Penelope W Coates
Mar 11, 2008·American Journal of Epidemiology·Xiang GaoAlberto Ascherio
Mar 6, 2015·Annals of the Rheumatic Diseases·Na LuHyon K Choi
Dec 7, 2007·Neurobiology of Aging·Johannes Everse, Penelope W Coates
Nov 1, 2008·Arthritis and Rheumatism·Mary De VeraHyon Choi
Sep 22, 2016·Cellular and Molecular Neurobiology·Tuane Bazanella SampaioCristina Wayne Nogueira
Dec 20, 2012·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Chunhong ShenMeiping Ding

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