The CYVADIC regimen as a combination chemotherapy treatment option for advanced soft tissue sarcomas originating from the non-extremities

Internal Medicine
Kenji NakanoShunji Takahashi

Abstract

Soft tissue sarcoma (STS) originating from the non-extremities has a poor prognosis and risk for visceral crisis; therefore, combination chemotherapy with a high response rate is desired. We retrospectively reviewed the cases of 30 patients with advanced STS that originated from the non-extremities who were treated between October 2005 and February 2012 at our institute with the CYVADIC chemotherapy regimen, which consists of cyclophosphamide, vincristine, doxorubicin, and dacarbazine. The patients' objective responses, progression-free survival (PFS), and overall survival (OS) were evaluated, and a statistical analysis was conducted to identify the predictive factors related to response and survival. The median follow-up time was 16.5 months. The response rate was 33%, the median PFS was 7.4 months, and the 1-year OS was 81% (the OS did not reach the median). The median number of treatment cycles was six. Eleven patients failed to complete 6 cycles due to disease progression. The number of involved organs (>3) was a significant predictive factor of early refractoriness by the logistic regression analysis. Thirteen patients had an objective response or PFS longer than 1 year, and an alkaline phosphatase (ALP) level within the n...Continue Reading

References

Feb 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael W KattanMurray F Brennan
Jul 16, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jürgen WeitzMurray F Brennan
Jul 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paul LoriganUNKNOWN European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group Study
Jun 25, 2009·Cancer Research·Isabelle Ray-CoquardUNKNOWN European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group
Jun 29, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P G CasaliUNKNOWN ESMO/CONTICANET/EUROBONET Consensus Panel of experts
Jul 4, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Axel Le CesneGeorge D Demetri

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