The D614G mutations in the SARS-CoV-2 spike protein: Implications for viral infectivity, disease severity and vaccine design.

Biochemical and Biophysical Research Communications
Danielle C GrovesAdrienn Angyal

Abstract

The development of the SARS-CoV-2 pandemic has prompted an extensive worldwide sequencing effort to characterise the geographical spread and molecular evolution of the virus. A point mutation in the spike protein, D614G, emerged as the virus spread from Asia into Europe and the USA, and has rapidly become the dominant form worldwide. Here we review how the D614G variant was identified and discuss recent evidence about the effect of the mutation on the characteristics of the virus, clinical outcome of infection and host immune response.

References

Jul 15, 2015·Proceedings of the National Academy of Sciences of the United States of America·Yuanyuan MaZihe Rao
Jan 25, 2020·The New England Journal of Medicine·Na ZhuUNKNOWN China Novel Coronavirus Investigating and Research Team
Feb 23, 2020·Science·Daniel WrappJason S McLellan
Mar 11, 2020·Cell·Alexandra C WallsDavid Veesler
Apr 25, 2020·Cell·Dongwan KimHyeshik Chang
May 6, 2020·Science·Yasunori WatanabeMax Crispin

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Citations

Feb 10, 2021·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Chia Siang Kow, Syed Shahzad Hasan
Apr 12, 2021·Biochemistry. Biokhimii︠a︡·Andrey V LetarovEugene E Kulikov
Apr 3, 2021·Emerging Infectious Diseases·Natalia Fintelman-RodriguesThiago Moreno L Souza
Jul 6, 2021·Indian Journal of Clinical Biochemistry : IJCB·Sagar DholariyaDigishaben Patel
Jun 24, 2021·Revista Do Instituto De Medicina Tropical De São Paulo·Ana Lucia Frugis YuTelma Regina Marques Pinto Carvalhanas
Jul 3, 2021·Journal of Clinical Medicine·Thi Loi DaoPhilippe Gautret
Aug 3, 2021·Infection·Ahmed M AlmehdiSameh S M Soliman
Aug 28, 2021·Signal Transduction and Targeted Therapy·Yu-Wen ZhouXue-Lei Ma

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Methods Mentioned

BETA
glycosylation

Software Mentioned

GISAID

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