The D614G mutations in the SARS-CoV-2 spike protein: Implications for viral infectivity, disease severity and vaccine design.

Biochemical and Biophysical Research Communications
Danielle C GrovesAdrienn Angyal


The development of the SARS-CoV-2 pandemic has prompted an extensive worldwide sequencing effort to characterise the geographical spread and molecular evolution of the virus. A point mutation in the spike protein, D614G, emerged as the virus spread from Asia into Europe and the USA, and has rapidly become the dominant form worldwide. Here we review how the D614G variant was identified and discuss recent evidence about the effect of the mutation on the characteristics of the virus, clinical outcome of infection and host immune response.


Jul 15, 2015·Proceedings of the National Academy of Sciences of the United States of America·Yuanyuan MaZihe Rao
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Feb 23, 2020·Science·Daniel WrappJason S McLellan
Mar 11, 2020·Cell·Alexandra C WallsDavid Veesler
Apr 25, 2020·Cell·Dongwan KimHyeshik Chang
May 6, 2020·Science·Yasunori WatanabeMax Crispin

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