The daidzein- and estradiol- induced anorectic action in CCK or leptin receptor deficiency rats

Bioscience, Biotechnology, and Biochemistry
Mina FujitaniTaro Kishida

Abstract

We investigated the effect of daidzein feeding and estradiol treatment on food intake in cholecystokinin-1 receptor (CCK1R) deficiency, leptin receptor (ObRb) deficiency rats and their wild-type rats. These rats underwent an ovariectomy or a sham operation. For the 5 week experiment, each rat was divided in three groups: control, daidzein (150 mg/kg diet), and estradiol (4.2 μg/rat/day) groups. In both CCK1R+ and CCK1R- rats, daidzein feeding and estradiol treatment significantly decreased food intake. Daidzein feeding significantly reduced food intake in ovariectomized ObRb- rats, although not in ObRb+ rats. Estradiol treatment significantly lowered food intake in ovariectomized ObRb+ and ObRb- rats. In the ovariectomized rats, estradiol treatment significantly increases uterine weight, while daidzein feeding did not change it, suggesting that daidzein might have no or weak estrogenic effect in our experiment. These results suggest that CCK1R and ObRb signalings were not essential for the daidzein- and estradiol-induced anorectic action.

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Citations

May 9, 2015·Bioscience, Biotechnology, and Biochemistry·Mina FujitaniTaro Kishida
Feb 19, 2020·Bioscience, Biotechnology, and Biochemistry·Sudhashree AdhikariTaro Kishida
Oct 22, 2020·Medicinal Research Reviews·Ana T RufinoEduarda Fernandes
Jan 1, 2021·International Journal of Molecular Sciences·Alina Kuryłowicz

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

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