The damaging effect of UV rays below 320 nm on the rabbit anterior eye segment. II. Enzyme histochemical changes and plasmin activity after prolonged irradiation

Acta histochemica
J Cejková, Z Lojda

Abstract

Prolonged irradiation of the rabbit eyes with UVB rays (312 nm) caused serious enzymatic disturbances in the cornea and lens and the development of an inflammatory reaction in the whole anterior eye segment, particularly in the cornea. In the corneal stroma many inflammatory cells with high activities of acid glycosidases and lysosomal proteases were present. This was accompanied with significantly elevated plasmin activity in the tear fluid (1.6 IU/ml). Plasmin appeared also in the aqueous humour (0.8 IU/ml). For the treatment of these changes catalase (1 mg/1 ml saline), aprotinin (100 micrograms/1 ml saline) and catalase-aprotinin mixture (1:1) were applied on the eye surface during irradiation. The catalase-aprotinin mixture was most efficient and decreased plasmin activity in the tear fluid and diminished disturbances of the anterior eye segment. Obviously both, active oxygen species and elevated plasmin activity in the tear fluid contribute to the damage of the anterior eye segment and development of intracorneal inflammation after irradiation of the eye with UVB rays.

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Citations

Dec 10, 2002·American Journal of Ophthalmology·George G KoliakosAmund Ringvold
Mar 27, 1999·Journal of Photochemistry and Photobiology. B, Biology·K Maeda, M Naganuma
Feb 27, 2013·Journal of Cosmetic Dermatology·Tsz Wah Tse, Edith Hui
Jun 15, 2013·Oxidative Medicine and Cellular Longevity·Ichiya SanoAkihiro Ohira
Jun 19, 2016·Photochemistry and Photobiology·Taras ArdanJan Motlík
Apr 20, 2004·Progress in Retinal and Eye Research·Nick Di GirolamoDenis Wakefield

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