The dangers of widespread nitric oxide screening for primary ciliary dyskinesia

Thorax
Samuel A CollinsJane S Lucas

Abstract

Primary ciliary dyskinesia (PCD) is underdiagnosed and requires complex testing at specialist diagnostic centres. Measurement of nasal nitric oxide (nNO) has good sensitivity and specificity screening for PCD, but is currently usually measured at PCD centres rather than prior to referral. Proposals to include NO testing for asthma diagnoses could widen access to PCD screening if nasal mode analysers are available. Data from 282 consecutive referrals to our PCD diagnostic centre (31 PCD positive) were used to model predictive values for nNO testing with varying pretest probability and showed that predictive values were good in the referral population, but extending screening to more general populations would result in excessive false positives that may overwhelm diagnostic services. Although nNO remains a useful test, a 'normal' result with classical clinical history should still be considered for further testing.

References

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Citations

Jan 18, 2017·European Respiratory Review : an Official Journal of the European Respiratory Society·Nisreen RummanJane S Lucas
Aug 6, 2016·The European Respiratory Journal·Laura BehanJane S Lucas
Sep 13, 2017·Breathe·Claudia E Kuehni, Jane S Lucas
Jun 23, 2018·The European Respiratory Journal·Jane S Lucas, Woolf T Walker
Oct 2, 2019·Translational Science of Rare Diseases·Margaret W LeighMichael R Knowles
Nov 27, 2019·Annals of the American Thoracic Society·Adam J ShapiroMargaret W Leigh
Mar 9, 2017·NPJ Primary Care Respiratory Medicine·James D Chalmers, Sanjay Sethi
Jun 4, 2016·Annals of the American Thoracic Society·Claudia E Kuehni, Jane S Lucas
Oct 21, 2016·Expert Review of Respiratory Medicine·Eleonora DehlinkAndrew Bush
Aug 29, 2018·Multidisciplinary Respiratory Medicine·Martina ContariniJames D Chalmers
May 13, 2017·Archives of Disease in Childhood. Education and Practice Edition·Kim Simpson, Malcolm Brodlie
Apr 8, 2020·Archivos de bronconeumología·Noelia Baz-RedónAntonio Moreno-Galdó
Apr 17, 2021·Pediatric Pulmonology·Nicole BeydonGuillaume Thouvenin

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