The dark side of the spoon - glucose, ketones and COVID-19: a possible role for ketogenic diet?

Journal of Translational Medicine
Antonio PaoliMassimiliano Caprio

Abstract

The novel coronavirus disease (COVID-19) is posing a serious challenge to the health-care systems worldwide, with an enormous impact on health conditions and loss of lives. Notably, obesity and its related comorbidities are strictly related with worse clinical outcomes of COVID-19 disease. Recently, there is a growing interest in the clinical use of ketogenic diets (KDs), particularly in the context of severe obesity with related metabolic complications. KDs have been proven effective for a rapid reduction of fat mass, preserving lean mass and providing an adequate nutritional status. In particular, the physiological increase in plasma levels of ketone bodies exerts important anti-inflammatory and immunomodulating effects, which may reveal as precious tools to prevent infection and potential adverse outcomes of COVID-19 disease. We discuss here the importance of KDs for a rapid reduction of several critical risk factors for COVID-19, such as obesity, type 2 diabetes and hypertension, based on the known effects of ketone bodies on inflammation, immunity, metabolic profile and cardiovascular function. We do believe that a rapid reduction of all modifiable risk factors, especially obesity with its metabolic complications, should b...Continue Reading

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Citations

Mar 7, 2021·International Journal of Molecular Sciences·Barbara MalinowskaEberhard Schlicker
Apr 4, 2021·Nutrients·Elena GangitanoCarla Lubrano
Mar 30, 2021·Frontiers in Endocrinology·Danfei LiuLimin Xia
Aug 21, 2021·Applied Microbiology and Biotechnology·Aliya YaoGuo-Qiang Chen

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