The dark side of tumor-associated endothelial cells

Seminars in Immunology
Francesco De SanctisAndrea Facciabene

Abstract

Angiogenesis is a hallmark of cancer and a requisite that tumors must achieve to fulfill their metabolic needs of nutrients and oxygen. As a critical step in cancer progression, the 'angiogenic switch' allows tumor cells to survive and grow, and provides them access to vasculature resulting in metastatic progression and dissemination. Tumor-dependent triggering of the angiogenic switch has critical consequences on tumor progression which extends from an increased nutrient supply and relies instead on the ability of the tumor to hijack the host immune response for the generation of a local immunoprivileged microenvironment. Tumor angiogenic-mediated establishment of endothelial anergy is responsible for this process. However, tumor endothelium can also promote immune tolerance by unbalanced expression of co-stimulatory and co-inhibitory molecules and by releasing soluble factors that restrain T cell function and induce apoptosis. In this review, we discuss the molecular properties of the tumor endothelial barrier and endothelial anergy and discuss the main immunosuppressive mechanisms triggered by the tumor endothelium. Lastly, we describe the current anti-angiogenic therapeutic landscape and how targeting tumor angiogenesis can...Continue Reading

Citations

May 18, 2018·Journal of Biophotonics·Federico BoschiAntonello E Spinelli
Feb 27, 2020·Advanced Healthcare Materials·Shantanu PradhanJohn H Slater
Sep 27, 2018·Frontiers in Oncology·Diana Klein
Dec 14, 2018·Frontiers in Immunology·Monika C Brunner-Weinzierl, Christopher E Rudd
Aug 11, 2019·Molecular Cancer·Yongmei LiuWenhua Xu
Jan 11, 2020·Frontiers in Immunology·Sonal PatelSamit Chattopadhyay
Jun 6, 2020·Frontiers in Immunology·Alireza Labani-MotlaghAngelica Loskog
Feb 26, 2019·Frontiers in Immunology·Nicole Salazar, Brian A Zabel
Mar 7, 2020·Frontiers in Oncology·Rosalinda TrovatoFrancesco De Sanctis
Dec 11, 2019·International Journal of Molecular Sciences·Alessia BrossaBenedetta Bussolati
Jan 27, 2021·Annual Review of Pathology·Stefano UgelVincenzo Bronte
Dec 1, 2019·Translational Oncology·Shangwei ZhongJun-Li Luo
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Mar 31, 2021·Cancer Metastasis Reviews·Victor Delprat, Carine Michiels
May 25, 2021·Journal of the American Heart Association·Wei YuanBin Wang
Jun 15, 2021·Frontiers in Immunology·Khalil KhalafMariusz Kaczmarek
Oct 26, 2021·Inorganic Chemistry·Katrina M MirandaDavid A Wink
Jan 14, 2022·Journal for Immunotherapy of Cancer·Francesco De SanctisVincenzo Bronte

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