The DAS28 in rheumatoid arthritis and fibromyalgia patients

Rheumatology
B LeebB Rintelen

Abstract

To compare the DAS28 (Disease Activity Score including a 28-joint count) values of rheumatoid arthritis (RA) and fibromyalgia (FM) patients, and to establish whether high pain levels and impaired mood influence DAS28 values. DAS28 values were calculated in 62 consecutive patients with RA and in 26 patients suffering from FM. Values for DAS28 scores as well as for the single items of the patient cohorts were compared using Student's t-tests. To evaluate the item weighting and internal consistency of the total score factor analysis was performed and Cronbach's alpha calculated. RA patients showed a mean DAS28 score of 4.23 (+/-1.2; range 0.77-7.46) and in FM patients the mean DAS28 came to 4.04 (+/-1.13; range 1.19-6.28). DAS28 values of RA and FM patients were not significantly different statistically. Comparing the single components of the score, however, highly significant differences (P<0.0005) occurred between RA and FM patients. Cronbach's alpha for the DAS28 in RA patients amounted to 0.7329, indicating high internal consistency, whereas in FM patients it was 0.4832. The DAS28, as expected, proved to be inappropriate to express disease activity in FM patients. DAS28 values for expressing disease activity in RA patients may...Continue Reading

Citations

Oct 31, 2012·Current Pain and Headache Reports·David A Walsh, Daniel F McWilliams
Aug 27, 2009·Rheumatology·Kimme L HyrichUNKNOWN British Society for Rheumatology Biologics Register
Jan 27, 2010·Rheumatology·Louise C PollardDavid L Scott
Mar 24, 2010·Rheumatology·Chris DeightonUNKNOWN on behalf of BSR Clinical Affairs Committee & Standards, Audit and Guidelines Working Group and the BHPR
May 19, 2011·Rheumatology·Zoe Paskins, Andrew B Hassell
Feb 9, 2013·Rheumatology·Shintaro HirataCornelia F Allaart
Aug 16, 2005·Annals of the Rheumatic Diseases·S Irvine, H C Capell
Apr 16, 2013·PloS One·Michael CentolaJeffrey R Curtis
Nov 27, 2007·Joint, Bone, Spine : Revue Du Rhumatisme·Bruno FautrelUNKNOWN Société Française de Rhumatologie
Nov 28, 2007·The British Journal of Radiology·F P P MartinsL M B da Fonseca
Oct 14, 2008·Expert Opinion on Biological Therapy·Theodorus van den BroekSalvatore Albani
May 21, 2009·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Jarred Younger, Sean Mackey
Jul 7, 2012·Mayo Clinic Proceedings·John M DavisUNKNOWN European League Against Rheumatism
Nov 8, 2011·Seminars in Arthritis and Rheumatism·Christian DejacoMichael Schirmer
Dec 17, 2008·The Journal of Pain : Official Journal of the American Pain Society·Mary-Ann FitzcharlesYoram Shir
Dec 2, 2008·Best Practice & Research. Clinical Rheumatology·Henning BliddalSøren Torp-Pedersen
Jul 22, 2008·Rheumatic Diseases Clinics of North America·Mary-Ann Fitzcharles, Yoram Shir
Jul 3, 2007·Best Practice & Research. Clinical Rheumatology·Henning Bliddal, Bente Danneskiold-Samsøe
May 5, 2012·Arthritis Care & Research·Daniel F McWilliamsDavid A Walsh
May 28, 2015·International Journal of Rheumatic Diseases·Ilker SengulTaciser Kaya
Sep 4, 2015·Arthritis Research & Therapy·Sanne M W KoopMart A F J van de Laar
Dec 19, 2012·Free Radical Biology & Medicine·Paul EggletonPaul G Winyard
Aug 13, 2015·Best Practice & Research. Clinical Rheumatology·Fabiola AtzeniPiercarlo Sarzi-Puttini
Dec 18, 2014·Acta Odontologica Scandinavica·Neveen AhmedPer Alstergren
Apr 22, 2016·Current Rheumatology Reports·Sean D BoydenYvonne C Lee
Oct 15, 2011·Annals of Physical and Rehabilitation Medicine·W HamdiM M Kchir
Mar 16, 2017·International Journal of Rheumatic Diseases·Anthea C GistGeoffrey O Littlejohn
Mar 17, 2017·Joint, Bone, Spine : Revue Du Rhumatisme·Maxime Dougados, Serge Perrot
Oct 18, 2011·The Journal of Rheumatology·Evelien TonUNKNOWN Utrecht Rheumatoid Arthritis Cohort Study Group
Feb 12, 2009·The Journal of Rheumatology·Heidi Mäkinen, Pekka Hannonen
Jan 10, 2009·The Journal of Rheumatology·Fabienne CouryJacques G Tebib

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