The DDB1a interacting proteins ATCSA-1 and DDB2 are critical factors for UV-B tolerance and genomic integrity in Arabidopsis thaliana

The Plant Journal : for Cell and Molecular Biology
Sascha Biedermann, Hanjo Hellmann

Abstract

The integrity of the genome is a fundamental prerequisite for the well-being of all living organisms. Critical for the genomic integrity are effective DNA damage detection mechanisms that enable the cell to rapidly activate the necessary repair machinery. Here, we describe Arabidopsis thaliana ATCSA-1, which is an ortholog of the mammalian Cockayne Syndrome type-A protein involved in transcription-coupled DNA repair processes. ATCSA-1 is a critical component for initiating the repair of UV-B-induced DNA lesions, and, together with the damage-specific DNA binding protein 2 (DDB2), is necessary for light-independent repair processes in Arabidopsis. The transcriptional profile of both genes revealed that ATCSA-1 is strongly expressed in most tissues, whereas DDB2 is only weakly expressed, predominantly in the root tips and anthers of flowers. In contrast to ATCSA-1, DDB2 expression is rapidly inducible by UV treatment. Like DDB2, ATCSA-1 is localized to the nucleus, and assembles with DDB1 and CUL4 proteins into a complex. ATCSA-1 is an unstable protein that is degraded in a 26S proteasome-dependent manner. Overall, the results presented here form a functional description of a plant Cockayne syndrome factor A (CSA) ortholog, and d...Continue Reading

References

Jun 1, 1990·Journal of Photochemistry and Photobiology. B, Biology·J CadetW R Midden
Aug 25, 1995·Journal of Molecular Biology·S AbelA Theologis
Aug 1, 1993·Molecular Biology Reports·A I Lamond, M Carmo-Fonseca
May 9, 1998·Science·A I Lamond, W C Earnshaw
Mar 9, 1999·The Plant Journal : for Cell and Molecular Biology·S J Clough, A F Bent
Sep 10, 1999·Plant Molecular Biology·C XiangD J Oliver
Apr 25, 2000·The Journal of Biological Chemistry·W LiuS Linn
Dec 29, 2000·Nature·T MisteliD T Brown
May 7, 2002·Trends in Plant Science·Mansour KarimiAnn Depicker
Aug 6, 2002·Science·Hanjo Hellmann, Mark Estelle
Jan 1, 2003·Journal of Cell Science·Jesper Q Svejstrup
Mar 1, 2003·The Plant Journal : for Cell and Molecular Biology·Elena Ramirez-ParraCrisanto Gutierrez
May 30, 2003·Genes & Genetic Systems·DongTao FuTsukasa Matsunaga
Aug 2, 2003·Science·José M AlonsoJoseph R Ecker
Sep 12, 2003·DNA Repair·Birgitte Ø Wittschieben, Richard D Wood
Jul 31, 2004·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Sara S Dirscherl, Jocelyn E Krebs
Sep 21, 2004·Annual Review of Plant Biology·Jan Smalle, Richard D Vierstra
Feb 14, 2006·Proceedings of the National Academy of Sciences of the United States of America·Maria G KapetanakiArthur S Levine
Mar 11, 2006·The Journal of Biological Chemistry·Mohamed A El-MahdyAltaf A Wani
Jun 24, 2006·The Plant Journal : for Cell and Molecular Biology·Anne BernhardtHanjo Hellmann
Jun 27, 2006·Trends in Genetics : TIG·Jean-Philippe Lainé, Jean-Marc Egly
Aug 31, 2006·Molecular and Cellular Biology·Courtney A LovejoyDavid Cortez
Jan 2, 2007·DNA Repair·Mette Praetorius-IbbaAltaf A Wani
Apr 6, 2007·Genetics·Wesam M Al Khateeb, Dana F Schroeder
Dec 7, 2007·Molecular Genetics and Genomics : MGG·Joel Fernandes LimaGustavo Henrique Goldman
Feb 13, 2008·The Plant Journal : for Cell and Molecular Biology·Judit SafranyFerenc Nagy
Mar 28, 2008·The Plant Journal : for Cell and Molecular Biology·Songhu WangYongsheng Liu
Apr 25, 2008·Development·Esther M N DohmannClaus Schwechheimer

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Citations

May 26, 2010·Planta·Anne BernhardtHanjo Hellmann
Feb 25, 2011·Molecules and Cells·Jae-Hoon Lee, Woo Taek Kim
Oct 26, 2013·Plant Science : an International Journal of Experimental Plant Biology·Valentina LyDana F Schroeder
Dec 3, 2013·Molecular Genetics and Genomics : MGG·Qiang LiZhonghai Ren
Jun 13, 2012·Journal of Biomedicine & Biotechnology·Claudia P Spampinato, Diego F Gomez-Casati
Feb 14, 2012·Plant Science : an International Journal of Experimental Plant Biology·Johannes W Stratmann, Giuliana Gusmaroli
Dec 5, 2012·Journal of Integrative Plant Biology·Liquan GuoNing Wei
Dec 17, 2014·The Arabidopsis Book·Christina M ChoiHanjo Hellmann
Jan 12, 2013·Molecular Plant·Liyuan Chen, Hanjo Hellmann
Jan 13, 2015·Plant Science : an International Journal of Experimental Plant Biology·Valentina LyDana F Schroeder
Oct 27, 2016·Plant Molecular Biology·Christos N VelanisGareth I Jenkins
Dec 22, 2016·Cellular and Molecular Life Sciences : CMLS·Claudia P Spampinato
Dec 29, 2017·Genes·Triparna LahariDana F Schroeder
Nov 18, 2017·Science·Hua Tang, Gregory S Barsh
Oct 28, 2017·The Plant Journal : for Cell and Molecular Biology·Dolores Córdoba-CañeroJean Molinier
Mar 1, 2012·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Mika TeranishiJun Hidema
Oct 15, 2019·Frontiers in Plant Science·Sandra Fonseca, Vicente Rubio
Feb 11, 2020·Frontiers in Plant Science·Bin WangShijiang Zhu
May 21, 2019·Frontiers in Plant Science·Wesam M Al KhateebDana F Schroeder
Nov 12, 2015·Frontiers in Plant Science·Vasilissa Manova, Damian Gruszka
Dec 6, 2020·Genes·Wojciech StrzałkaAgnieszka Katarzyna Banaś

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